Sci-Fri PM: Radiation Therapy, Planning, Imaging, and Special Techniques - 07: Transitioning from extended-distance total body irradiation to optimized VMAT total marrow irradiation

Authors

  • Cherpak Amanda,

    1. Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS
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  • Chytyk-Praznik Krista,

    1. Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS
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  • Yewondwossen Mammo,

    1. Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS
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  • Schella Jason,

    1. Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS
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  • Davis Carol-Anne,

    1. Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS
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  • Day Allan,

    1. Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS
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  • DeGiobbi Jennifer,

    1. Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS
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  • McAloney Dave,

    1. Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS
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  • Mulroy Liam

    1. Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Department of Physics and Atmospheric Sciences, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Nova Scotia Cancer Centre, Nova Scotia Health Authority, Halifax, NS, Department of Radiation Oncology, Dalhousie University, Halifax, NS
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Abstract

Purpose:

TMI targets only the bone marrow, with the intent of sparing normal tissues. The NSCC has recently implemented a TMI protocol which includes VMAT fields to treat the bone marrow from head to mid-thigh and extended SSD POP fields to treat the lower legs. This work describes the commissioning and initial clinical results of the first reported VMAT TMI treatments in Canada.

Methods:

Detailed CT simulation, imaging, planning and treatment procedures were developed by a multi-disciplinary team. Patients have 1 cm of bolus over the lower legs and 0.5 cm of bolus around the lower arms. The PTV includes all bone, except mandible, facial bones and hands, with the objective of V(12 Gy) > 90%. Detailed analysis of the influence of field overlap was performed to determine optimal field placement and image-guidance tolerances.

Results:

PTV coverage was achieved for all cases as V(12 Gy) ranged from 90.4–96.3%. The minimum dose to the PTV, D(99%), ranged from 91.4–97.87% and V(90%Rx=10.8 Gy) ranged from 99.1–100.0%. The lungs, liver and heart had an average Dmean of (7.8±0.3)Gy/(65±2)%, (7.6±0.7)Gy/(63±5)%, and (6.8±0.4)Gy/(56±4)% respectively.

Conclusions:

Commissioning required input and collaboration from all team members. Transitioning from TBI to TMI requires additional time for contouring, treatment planning, QA, and treatment. Patient benefit can however be seen in the quality of OAR sparing.

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