NKT Cell Frequency in Japanese Type 1 Diabetes


Address for correspondence: Yoichi Oikawa, M.D., Department of Internal Medicine, Division of Endocrinology and Metabolism, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Voice: +81-3-3353-1211 (ext. 62383); fax: +81-3-5269-3219. y-oikawa@mvc.biglobe.ne.jp


Abstract: A numerical and functional deficit of natural killer T (NKT) cells has been reported to be associated with the pathogenesis of Caucasian patients with type 1 diabetes. However, a conflicting finding of a higher frequency of NKT cells (Valpha24+ Vbeta11+ T cells) was observed in islet-associated Ab+ and Ab− Japanese “classic” type 1 diabetes. Here, we combined the data of NKT cell frequency in Ab+ and Ab−“classic” type 1 diabetic patients and then analyzed the relationship between NKT cell frequency and disease activity.