*This paper is part of a Ph.D. thesis by Elisângela Farias-Silva.
Glucocorticoid Receptor and Beta-Adrenoceptor Expression in Epididymal Adipose Tissue from Stressed Rats
Article first published online: 16 JAN 2006
Annals of the New York Academy of Sciences
Volume 1018, Stress: Current Neuroendocrine and Genetic Approaches pages 328–332, June 2004
How to Cite
FARIAS-SILVA, E., DOS SANTOS, I. N., DO AMARAL, M. E. C., GRASSI-KASSISSE, D. M. and SPADARI-BRATFISCH, R. C. (2004), Glucocorticoid Receptor and Beta-Adrenoceptor Expression in Epididymal Adipose Tissue from Stressed Rats. Annals of the New York Academy of Sciences, 1018: 328–332. doi: 10.1196/annals.1296.040
- Issue published online: 16 JAN 2006
- Article first published online: 16 JAN 2006
- white adipose tissue;
- glucocorticoid receptor
Abstract: Adipocytes isolated from epididymal adipose tissue of foot-shock stressed rats are supersensitive to isoprenaline and subsensitive to norepinephrine. These alterations are probably mediated by a stress-induced increase in plasma corticosterone levels. We investigated whether foot-shock stress modifies the expression of glucocorticoid receptors (GRs) and β-adrenergic protein receptors (β-ARs) in epididymal adipose tissue from rats submitted to one daily foot-shock session on three consecutive days. This stress protocol caused decreases in GR, β1-AR, and β3-AR protein levels, but caused an increase in β2-AR. These results confirm and support previous functional studies. The alterations in protein expression may be modulated by the high corticosterone levels that downregulate the glucocorticoid receptor.