Oxidative Stress to Dopaminergic Neurons as Models of Parkinson's Disease


Address for correspondence: Wolf-Dieter Rausch, Institute of Medical Chemistry, Veterinary University of Vienna, Veterinärplatz 1, A-1210 Vienna, Austria. Voice: (0043) 1-25077-4209; fax: (0043) 1-25077-4290. e-mail: wolf.rausch@vu-wien.ac.at


Abstract: The effects of exogenous toxins (MPP+, rotenone) and potentially neurotoxic properties of levodopa (L-DOPA) on the survival rate of dopaminergic neurons in dissociated primary culture are presented. Dopamine agonists show a capacity to counteract MPP+-toxicity. Moreover, a preserving potential of the antioxidant and bioenergetic coenzyme Q10 (CoQ10) on the activities of tyrosine hydroxylase (TH), complexes I and II of the respiratory chain, and hexokinase activity in striatal slice cultures against MPP+ is demonstrated.