Metabolic Substrates of Neuronal Aging


Address for correspondence: E. C. Toescu, Department of Physiology, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Voice: +44-121-414-6927; fax: +44-121-414-6924.


Abstract: One mechanism proposed to explain age-dependent changes has been the “Ca2+ hypothesis” of aging. Data indicate that most changes in the Ca2+ homeostasis of the cerebellar granule neurons appear only when the aged neurons are exposed to higher levels of stimulation and that these changes are secondary to metabolic limitations imposed by altered mitochondrial function.