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Keywords:

  • ubiquitin;
  • mutant;
  • transgenic;
  • mice;
  • life span;
  • K48R

Abstract: The K48R mutant ubiquitin can exert profound in vivo protective effects against a variety of insults, including agents of direct clinical relevance. The manipulation of the ubiquitin/proteasome pathway has enormous potential for clinical benefit, and it is not unreasonable to expect that such benefits will include diseases of aging.