Mechanism of Superoxide-Mediated Damage Relevance to Mitochondrial Aging

Authors

  • I B AFANAS'EV

    Corresponding author
    1. Vitamin Research Institute, Moscow, Russia
      Address for correspondence: I. B. Afanas'ev, Vitamin Research Institute, Moscow, Russia. iafan@aha.ru
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Address for correspondence: I. B. Afanas'ev, Vitamin Research Institute, Moscow, Russia. iafan@aha.ru

Abstract

Abstract: The damaging effects of superoxide in mitochondria leading to pathological disorders and aging are well documented and usually ascribed to superoxide's role as a precursor of reactive free radical species. However, the latest findings point out the importance of the nucleophilic properties of superoxide and its ability to regulate heterolytic enzymatic processes. Hypothetical mechanisms of superoxide mediation of phosphorylation and dephosphorylation reactions with participation of protein kinases and the apoptotic protein BAD are considered.

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