Alpha-Lipoic Acid Increases Na+K+ATPase Activity and Reduces Lipofuscin Accumulation in Discrete Brain Regions of Aged Rats

Authors

  • P ARIVAZHAGAN,

    1. Department of Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, 600 113, India
    2. Department of Biochemistry, Kihara Institute for Biological Research, Yokohama City University, Maioka-cho 641-12, Totsuka-ku, Yokohama 244-0813, Japan
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  • C PANNEERSELVAM

    Corresponding author
    1. Department of Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, 600 113, India
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Address for correspondence: C. Panneerselvam, Department of Biochemistry, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai, 600 113, India. Fax: +91-44-24926709. panneerselvam@eth.net

Abstract

Abstract: A convincing link between oxidative stress and neurodegenerative diseases has been found with the knowledge that it actually damages neuronal cells in culture. We analyzed the effect of dl-α-lipoic acid on lipofuscin and Na+K+ ATPase in discrete brain regions of young and aged rats. In aged rats, the level of lipofuscin was increased, and the activity of Na+K+ATPase was decreased. Intraperitoneal administration of lipoic acid to aged rats led to a duration-dependent reduction and elevation in lipofuscin and enzyme activity, respectively, in the cortex, cerebellum, striatum, hippocampus, and hypothalamus of the brain. These results suggest that lipoic acid, a natural metabolic antioxidant, should be useful as a therapeutic tool in preventing neuronal dysfunction in aged individuals.

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