Effect of Caloric Restriction on the 24-Hour Plasma DHEAS and Cortisol Profiles of Young and Old Male Rhesus Macaques

  1. H F. URBANSKI1,*,
  2. J L DOWNS1,
  3. V T GARYFALLOU1,
  4. J A MATTISON2,
  5. M A LANE2,
  6. G S ROTH2,
  7. D K INGRAM2

Article first published online: 12 JAN 2006

DOI: 10.1196/annals.1297.081

Issue

Annals of the New York Academy of Sciences

Additional Information

How to Cite

URBANSKI, H. F., DOWNS, J. L., GARYFALLOU, V. T., MATTISON, J. A., LANE, M. A., ROTH, G. S. and INGRAM, D. K. (2004), Effect of Caloric Restriction on the 24-Hour Plasma DHEAS and Cortisol Profiles of Young and Old Male Rhesus Macaques. Annals of the New York Academy of Sciences, 1019: 443–447. doi: 10.1196/annals.1297.081

Author Information

  1. 1

    Division of Neuroscience, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA

  2. 2

    Laboratory of Experimental Gerontology, National Institute on Aging/National Institutes of Health, Baltimore, Maryland 21224, USA

*Address for correspondence: Henryk F. Urbanski, Ph.D., Division of Neuroscience, Oregon National Primate Research Center, 505 N.W. 185 th Avenue, Beaverton, OR 97006. Voice: 503-690-5306; fax: 503-690-5384. urbanski@ohsu.edu

Publication History

  1. Issue published online: 12 JAN 2006
  2. Article first published online: 12 JAN 2006

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (1441K)

Keywords:

  • dehydroepiandrosterone sulfate;
  • adrenal gland;
  • primate

Abstract: Although dietary caloric restriction (CR) can retard aging in laboratory rats and mice, it is unclear whether CR can exert similar effects in long-lived species, such as primates. Therefore, we tested the effect of CR on plasma levels of dehydroepiandrosterone sulfate (DHEAS), a reliable endocrine marker of aging. The study included six young (∼10 years) and ten old (∼25 years) male rhesus macaques, approximately half of the animals in each age group having undergone >4 years of 30% CR. Hourly blood samples were collected remotely for 24 hours, through a vascular catheter, and assayed for DHEAS and cortisol. Both of these adrenal steroids showed a pronounced diurnal plasma pattern, with peaks occurring in late morning, but only DHEAS showed an aging-related decline. More importantly, there was no significant difference in plasma DHEAS concentrations between the CR animals and age-matched controls. These data fail to support the hypothesis that CR can attenuate the aging-related decline in plasma DHEAS concentrations, at least not when initiated after puberty.

View Full Article (HTML) Get PDF (1441K)