Cirrhosis Progression as a Model of Accelerated Senescence: Affecting the Biological Aging Clock by a Breakthrough Biophysical Methodology

Authors

  • G MARINEO,

    Corresponding author
    1. Delta Research and Development, Research Center for Medical Bioengineering, Tor vergata University, Rome, Italy
      Address for correspondence: Dr. Giuseppe Marineo, Delta Research and Development, Via di Mezzocammino, 85, 00187 Roma, Italy. Voice: +39-065237-1173; fax: +39-065237-1171. g.marineo@mclink.it
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  • F MAROTTA,

    1. Delta Research and Development, Research Center for Medical Bioengineering, Tor vergata University, Rome, Italy
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  • G SISTI

    1. Delta Research and Development, Research Center for Medical Bioengineering, Tor vergata University, Rome, Italy
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Address for correspondence: Dr. Giuseppe Marineo, Delta Research and Development, Via di Mezzocammino, 85, 00187 Roma, Italy. Voice: +39-065237-1173; fax: +39-065237-1171. g.marineo@mclink.it

Abstract

Abstract: To test new treatment modalities, a pilot study with a novel noninvasive biophysical methodology (Delta-S DVD) that can artificially exert a “decrease of entropy” through the patented electromagnetic-driven delivery of “energy clusters” was designed. This process has been modulated and integrated by the body as a “self” source to support the energy-dependent functional stores, thus modifying reparative into regenerative mechanisms of liver parenchyma. Seven long-standing hepatitis C virus-positive (Child A-B) cirrhosis patients with overt symptoms and portal hypertension and failure or side effects of antiviral drug treatment underwent 40-min sessions of Delta-S DVD daily for six months and were followed up monthly. At the end of the first month, rapid improvement of symptoms and a decrease of portal hypertension were noted. At the end of treatment, all patients showed either a complete (80%) or a partial (20%) regression of fatigue (FISK score), peripheral edema, pruritus, and palmar erythema. As observed, despite having stopped beta-blockers, F1 esophageal varices disappeared (60%), whereas F2 decreased to F1. The Doppler ultrasound aspect of partial (40%) or total (20%) atrophy was either reduced (60%) or reverted to normal (20%), and the respiratory dynamics of the portal vein improved (80%) or normalized (20%), whereas gross scarring nodules disappeared in 40% of cases. These promising data pave the way for an innovative physiopathological approach with extensive clinical applications.

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