How the Gut Links Innate and Adaptive Immunity

Authors

  • MARTIN RUMBO,

    1. Swiss Institute for Experimental Cancer Research and the Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland
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  • PASCALE ANDERLE,

    1. Swiss Institute for Experimental Cancer Research and the Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland
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  • ARNAUD DIDIERLAURENT,

    1. Swiss Institute for Experimental Cancer Research and the Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland
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  • FRÉDÉRIC SIERRO,

    1. Swiss Institute for Experimental Cancer Research and the Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland
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  • NATHALIE DEBARD,

    1. Swiss Institute for Experimental Cancer Research and the Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland
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  • JEAN-CLAUDE SIRARD,

    1. Equipe AVENIR-INSERM d'Immunité Anti-Microbienne des Muqueuses, Institut de Biologie de Lille, 1 rue du Professeur Calmette-BP 447-59021 Lille, France
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  • DANIELA FINKE,

    1. Pharmacenter-DKBW, University of Basel, Klingelbergstrasse 50–70, CH-4056 Basel, Switzerland
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  • JEAN-PIERRE KRAEHENBUHL

    Corresponding author
    1. Swiss Institute for Experimental Cancer Research and the Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland
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Address for correspondence: Jean-Pierre Kraehenbuhl, Swiss Institute for Experimental Cancer Research, CH-1066 Epalinges, Switzerland. Voice: +41-21-692-5856; fax: +41-21-652-6933. jean-pierre.kraehenbuhl@isrec.unil.ch

Abstract

Abstract: Mucosal surfaces represent the main sites in which environmental microorganisms and antigens interact with the host. Sentinel cells, including epithelial cells, lumenal macrophages, and intraepithelial dendritic cells, continuously sense the environment and coordinate defenses for the protection of mucosal tissues. The mucosal epithelial cells are crucial actors in coordinating defenses. They sense the outside world and respond to environmental signals by releasing chemokines and cytokines that recruit inflammatory and immune cells to control potential infectious agents and to attract cells able to trigger immune responses. Among immune cells, dendritic cells (DC) play a key role in controlling adaptive immune responses, due to their capacity to internalize foreign materials and to present antigens to naive T and B lymphocytes, locally or in draining organized lymphoid tissues. Immune cells recruited in epithelial tissues can, in turn, act upon the epithelial cells and change their phenotype in a process referred to as epithelial metaplasia.

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