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A Psychobiological Perspective on Genetic Determinants of Hypothalamus-Pituitary-Adrenal Axis Activity
Article first published online: 12 JAN 2006
DOI: 10.1196/annals.1314.005
Issue
1749-6632/asset/cover.gif?v=1&s=ab6276ce206ff2a11aab60a58914347cab6db545 "Annals of the New York Academy of Sciences")
Annals of the New York Academy of Sciences
Volume 1032, Biobehavioral Stress Response: Protective and Damaging Effects pages 52–62, December 2004
Additional Information
How to Cite
WÜST, S., FEDERENKO, I. S., van ROSSUM, E. F.C., KOPER, J. W., KUMSTA, R., ENTRINGER, S. and HELLHAMMER, D. H. (2004), A Psychobiological Perspective on Genetic Determinants of Hypothalamus-Pituitary-Adrenal Axis Activity. Annals of the New York Academy of Sciences, 1032: 52–62. doi: 10.1196/annals.1314.005
Publication History
- Issue published online: 8 JUL 2009
- Article first published online: 12 JAN 2006
- Abstract
- Article
- References
- Cited By
Keywords:
- hypothalamus-pituitary-adrenal axis;
- HPA;
- stress;
- glucocorticoids;
- genes;
- heritability;
- twins
Abstract: From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the hypothalamus-pituitary-adrenal (HPA) axis. Quantitative genetic studies in twins as well as association studies, primarily on polymorphisms in the glucocorticoid receptor gene, are depicted. Recent findings suggest that the collaboration of psychobiology and molecular genetics is a promising interdisciplinary approach that will significantly contribute to the understanding of the mechanisms underlying the link between stress, the HPA axis, and HPA-related clinical states.