Apoptosis Signaling in Tumor Therapy

Authors

  • SIMONE FULDA,

    Corresponding author
    1. University Children's Hospital, 89075 Ulm, Germany
      Address for correspondence: Dr. Simone Fulda, University Children's Hospital, Prittwitzstr. 43, D-89075 Ulm, Germany. Voice: +49-731-5002-5980; fax: +49-731-5002-6765. simone.fulda@medizin.uni-ulm.de
    Search for more papers by this author
  • KLAUS-MICHAEL DEBATIN

    1. University Children's Hospital, 89075 Ulm, Germany
    Search for more papers by this author

Address for correspondence: Dr. Simone Fulda, University Children's Hospital, Prittwitzstr. 43, D-89075 Ulm, Germany. Voice: +49-731-5002-5980; fax: +49-731-5002-6765. simone.fulda@medizin.uni-ulm.de

Abstract

Abstract: Apoptosis, the cell's intrinsic program to death, plays a central role in physiological growth control and regulation of tissue homeostasis. Tipping the balance between cell death and proliferation in favor of cell survival may result in tumor formation. Also, killing of cancer cells by cytotoxic therapies currently used for treatment of cancer, for example, chemotherapy, γ-irradiation, immunotherapy, or suicide gene therapy, largely depends on activation of apoptosis programs in cancer cells. Accordingly, failure to undergo apoptosis in response to anticancer therapy may result in cancer resistance. Further insights into the mechanisms regulating apoptosis in response to anticancer therapy and how cancer cells evade cell death may provide novel opportunities for drug development.

Ancillary