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Keywords:

  • immune response;
  • inflammatory bowel diseases;
  • intestine;
  • macrophages;
  • matrix metalloproteinase;
  • tissue inflammation

Abstract: Matrix metalloproteinases (MMPs) are involved in a number of physiological and pathologic processes including the inflammation found in IBD. We have shown that MMP-3 is upregulated in Crohn's disease and in ulcerative colitis. This study shows a potential role for MMP-12 in these idiopathic diseases.