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Role of Macrophage Metalloelastase in Gut Inflammation



This article is corrected by:

  1. Errata: Erratum for Ann. N.Y. Acad. Sci. 1072: 386–388 Volume 1126, 333, Article first published online: 23 April 2008

Address for correspondence: Dr. Sylvia L.F. Pender, Division of Infection, Inflammation, Repair, Mailpoint 813, Level E, South Academic Block, Southampton General Hospital, Southampton SO16 6YD, UK. Voice: +44-0-23-8079-5081; fax: +44-0-23-8079-5025.


Abstract: Matrix metalloproteinases (MMPs) are involved in a number of physiological and pathologic processes including the inflammation found in IBD. We have shown that MMP-3 is upregulated in Crohn's disease and in ulcerative colitis. This study shows a potential role for MMP-12 in these idiopathic diseases.