Cigarette Smoking Increases Human Vitamin E Requirements as Estimated by Plasma Deuterium-Labeled CEHC


Address for correspondence: Maret G. Traber, Ph.D., Linus Pauling Institute, 571 Weniger Hall, Oregon State University, Corvallis, OR 97331, USA. Voice: 541-737-7977; fax: 541-737-5077.


Abstract: Cigarette smoking (CS) is a well-described oxidant burden in humans. We hypothesized that CS would accelerate α-tocopherol (α-T) utilization leaving less for metabolite (CEHC) production. After labeled α-T consumption (75 mg each of d3-RRR-α-TAc and d6-all-rac-α-TAc) by smokers and nonsmokers (n= 10/group), CS increased α-T disappearance and decreased plasma and urinary CEHCs. Plasma d3/d6-α-T ratios were approximately 1.4 during supplementation and approximately 2 from days 5 to 17. d3/d6-α-CEHC ratios were on average 0.29 ± 0.05, confirming that all-rac-α-tocopherol is metabolized more efficiently. CEHC may be a good marker of vitamin E status, and smokers may have an increased vitamin E requirement.