γ-Tocotrienol Metabolism and Antiproliferative Effect in Prostate Cancer Cells

Authors


Address for correspondence: Francesco Galli, Ph.D., University of Perugia, Department of Internal Medicine, Section of Applied Biochemistry and Nutritional Sciences, Via del Giochetto, 06126 Perugia, Italy. fax: +39-075-585-7441. f.galli@unipg.it

Abstract

Abstract: In this study, we evaluated the antiproliferative effect of tocotrienols (T3) and the presence of a specific vitamin E metabolism in PC3 and LNCaP prostate cancer cells. These cell lines are able to transform tocopherols (T) and T3 in the corresponding carboxyethyl-hydroxychromans metabolites (CEHCs). The extent of this metabolism and the inhibitory effect on cell growth followed the order of magnitude α-T<α-T3<γ-T<γ-T3. The partial inhibition of γ-T3 metabolism by ketoconazole did not influence cell proliferation. These early findings may suggest that the transformation of vitamin E to CEHC is mostly a detoxification mechanism useful to maintain the malignant properties of prostate cancer cells.

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