DNA Damage-Induced Programmed Cell Death: Potential Roles in Germ Cell Development

Authors

  • YUKIKO YAMADA,

    Corresponding author
    1. Department of Genetics, Development and Cell Biology, Iowa State University, Ames, Iowa 50011, USA
    • Address for correspondence: Yukiko Yamada, Department of Genetics, Development and Cell Biology, Iowa State University, 3238 Molecular Biology Building, Ames, IA 50011–3260. Voice: 515-294-4734, fax: 515-294-6755. yukiko@iastate.edu

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  • CLARK R. COFFMAN

    1. Department of Genetics, Development and Cell Biology, Iowa State University, Ames, Iowa 50011, USA
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Abstract

Abstract: The detection of DNA damage is necessary to protect against proliferation of potentially harmful cells and often results in cell cycle arrest and programmed cell death. Key components of DNA damage signaling networks include ATM, CHK2, p53, and Bax. Mutations in these damage signaling systems are linked to tumorigenesis and developmental abnormalities. Expression of some of these genes in primordial germ cells (PGCs) argues that PGCs may utilize DNA damage-induced signaling mechanisms to select against germ cells that are genetically defective, thus maintaining the integrity of the germline. This paper summarizes the roles of these DNA damage signaling molecules and addresses their potential involvement in germ cell development.

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