Grafted Neural Stem Cells Shield the Host Environment from Oxidative Stress

Authors

  • LALITHA MADHAVAN,

    1. Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
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  • VÁCLAV OUREDNIK,

    1. Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
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  • JITKA OUREDNIK

    Corresponding author
    1. Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
    • Address for correspondence: Dr. Jitka Ourednik, Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011. Voice and fax: +1-515-294-6449. joured@iastate.edu

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Abstract

Abstract: Here, we present our preliminary data showing that neural stem cells (NSCs) can prevent the degeneration of striatal neurons when transplanted into the CNS prior to intoxication with 3-nitropropionic acid (3-NP). In the adult CNS, the number of NSCs, a major source of neural cell populations and plasticity-modulating factors, is relatively low if compared to that of the developing brain. This, together with the adult growth-inhibitory environment, limits its regenerative capacity. Our recent observation has shown that grafted NSCs may rescue/protect neurons in the chronically impaired mesostriatal system. On the basis of this study and because we were also intrigued by our recent observations regarding the rescue/protective role of NSCs in vitro, we decided to test the hypothesis that grafted NSCs can also be deposited preventively in the CNS (and perhaps join the pool of endogenous NSCs of the intact host brain) for later buffering and maintenance of homeostasis when the host is exposed to oxidative stress.

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