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A Theoretical Study of Hypothalamo-Pituitary-Adrenocortical Axis Dynamics

Authors

  • DANKA SAVIĆ,

    Corresponding author
    1. Institute of Nuclear Sciences “Vinča,” Laboratory for Theoretical and Condensed Matter Physics, Belgrade, Serbia and Montenegro
    • Address for correspondence: Danka Savić, Institute of Nuclear Sciences Vinča, Laboratory for Theoretical and Condensed Matter Physics (020/2), P.O. Box 522, Belgrade 11001, Serbia and Montenegro. Voice: 38-11-8065828; fax: 38-11-8065828. dankasav@eunet.yu

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  • SMILJANA JELIĆ

    1. Institute of Nuclear Sciences “Vinča,” Laboratory for Theoretical and Condensed Matter Physics, Belgrade, Serbia and Montenegro
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Abstract

Abstract: Does the hypothalamo-pituitary-adrenocortical (HPA) axis itself generate oscillations? The affirmative answer to this question is commonly assumed, because a regular daily rhythm of its hormones is observed. We offer another plausible explanation of the origin of this pattern: HPA just responds to an external pacemaker. A qualitative mathematical model is constructed wherein all the terms in the equations are physicochemically interpretable. Linear stability analysis shows that this system does not generate oscillations. Computer simulation yields oscillations that are the system's response to an external pulsing activator, implying that the observed pattern does not have to be an intrinsic property of this system.

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