Would Carnosine or a Carnivorous Diet Help Suppress Aging and Associated Pathologies?
Version of Record online: 10 MAY 2006
Annals of the New York Academy of Sciences
Volume 1067, Understanding and Modulating Aging pages 369–374, May 2006
How to Cite
HIPKISS, A. R. (2006), Would Carnosine or a Carnivorous Diet Help Suppress Aging and Associated Pathologies?. Annals of the New York Academy of Sciences, 1067: 369–374. doi: 10.1196/annals.1354.052
- Issue online: 10 MAY 2006
- Version of Record online: 10 MAY 2006
- anti glycators;
Abstract: Carnosine (β-alanyl-l-histidine) is found exclusively in animal tissues. Carnosine has the potential to suppress many of the biochemical changes (e.g., protein oxidation, glycation, AGE formation, and cross-linking) that accompany aging and associated pathologies. Glycation, generation of advanced glycosylation end-products (AGEs), and formation of protein carbonyl groups play important roles in aging, diabetes, its secondary complications, and neurodegenerative conditions. Due to carnosine's antiglycating activity, reactivity toward deleterious carbonyls, zinc- and copper-chelating activity and low toxicity, carnosine and related structures could be effective against age-related protein carbonyl stress. It is suggested that carnivorous diets could be beneficial because of their carnosine content, as the dipeptide has been shown to suppress some diabetic complications in mice. It is also suggested that carnosine's therapeutic potential should be explored with respect to neurodegeneration. Olfactory tissue is normally enriched in carnosine, but olfactory dysfunction is frequently associated with neurodegeneration. Olfactory administration of carnosine could provide a direct route to compromised tissue, avoiding serum carnosinases.