Short- and Long-Term Immune Responses of CD-1 Outbred Mice to the Scrub Typhus DNA Vaccine Candidate: p47Kp

Authors

  • GUANG XU,

    1. Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA
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  • SUCHISMITA CHATTOPADHYAY,

    1. Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA
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  • JU JIANG,

    1. Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA
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  • TEIK-CHYE CHAN,

    1. Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA
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  • CHIEN-CHUNG CHAO,

    1. Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA
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  • WEI-MEI CHING,

    1. Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA
    2. Department of Preventive Medicine and Biometrics, Uniformed Services University of Health Sciences, Bethesda, Maryland, USA
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  • ALLEN L. RICHARDS

    Corresponding author
    1. Rickettsial Diseases Department, Naval Medical Research Center, Silver Spring, Maryland, USA
    2. Department of Preventive Medicine and Biometrics, Uniformed Services University of Health Sciences, Bethesda, Maryland, USA
      Address for correspondence: Allen L. Richards, Rickettsial Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910-7500. Voice: 301-319-7668; fax: 301-319-9458. richardsa@nmrc.navy.mil
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Address for correspondence: Allen L. Richards, Rickettsial Diseases Department, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910-7500. Voice: 301-319-7668; fax: 301-319-9458. richardsa@nmrc.navy.mil

Abstract

Abstract: Orientia tsutsugamushi is an obligate intracellular bacterium that is the causative agent of scrub typhus. To develop an effective vaccine to prevent or ameliorate scrub typhus, knowledge of the protective immune response to O. tsutsugamushi needs to be ascertained. Our laboratory has demonstrated that the DNA vaccine vector pVR1012 carrying the O. tsutsugamushi Karp strain 47-kDa protein gene (p47Kp) consistently provides outbred mice protection against homologous challenge.

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