Fermented Wheat Germ Extract (Avemar) in the Treatment of Cancer and Autoimmune Diseases

Authors


Address for correspondence: Prof. Yehuda Shoenfeld, M.D., FRCP (Hon.), Head, Department of Medicine ‘B’ and Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer 52621, Israel. Voice: +972-3-530-2652; fax: +972-3-535-2855. shoenfel@post.tau.ac.il

Abstract

Abstract: Avemar, the product of industrial fermentation of wheat germ, possesses unique cancer-fighting characteristics. Taken orally, Avemar can inhibit metastatic tumor dissemination and proliferation during and after chemotherapy, surgery, or radiation. Benefits of Avemar treatment have been shown in various human cancers, in cultures of in vitro grown cancer cells, in the prevention of chemical carcinogenesis, and also in some autoimmune conditions. This document reviews the clinical and experimental results obtained with this extract so far. Special references are made for its safety, including its coadministration with anticancer drugs, as well as for its immunomodulatory activity, its molecular targets, and its use in cancer clinical trials.

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