Rationale for T Cell Inhibition by Cyclosporin A in Major Autoimmune Diseases


Address for correspondence: G. F. Ferraccioli, M.D., Professor of Rheumatology, Catholic University of the Sacred Heart, Division of Rheumatology, Complesso Integrato Columbus Via Moscati 31, 00168 Rome, Italy. Voice: +39-06-3503-654; fax: +39-06-3503-523. gf.ferraccioli@rm.unicatt.it


Abstract: T cells exert a fundamental role in different autoimmune chronic inflammatory diseases. The low-affinity autoreactive T cell clones provide the first amplification loop after the antigen (AgX) presentation, and if not counterregulated by the T regulatory cells (Treg), they maintain the inflammation and predispose to organ damage. Interrupting the T cell amplification loop through calcineurin antagonists leads to maintenance of the whole process under the autoimmune threshold.