Modulation of Acute and Chronic Inflammation of the Lung by GITR and its Ligand

Authors

  • GIUSEPPE NOCENTINI,

    1. Dipartimento di Medicina Clinica e Sperimentale, Sezione di Farmacologia, Tossicologia e Chemioterapia, Università di Perugia; and IBiT Foundation, Perugia and Polo Scientifico e Didattico di Terni, Terni, Italy
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  • SALVATORE CUZZOCREA,

    1. Dipartimento Clinico e Sperimentale di Medicina e Farmacologia, Torre Biologica, Policlinico Universitario, Messina, Italy; and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Centro neurolesi “Bonino-Pulejo,” Messina, Italy
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  • RODOLFO BIANCHINI,

    1. Dipartimento di Medicina Clinica e Sperimentale, Sezione di Farmacologia, Tossicologia e Chemioterapia, Università di Perugia; and IBiT Foundation, Perugia and Polo Scientifico e Didattico di Terni, Terni, Italy
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  • EMANUELA MAZZON,

    1. Dipartimento Clinico e Sperimentale di Medicina e Farmacologia, Torre Biologica, Policlinico Universitario, Messina, Italy; and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Centro neurolesi “Bonino-Pulejo,” Messina, Italy
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  • CARLO RICCARDI

    1. Dipartimento di Medicina Clinica e Sperimentale, Sezione di Farmacologia, Tossicologia e Chemioterapia, Università di Perugia; and IBiT Foundation, Perugia and Polo Scientifico e Didattico di Terni, Terni, Italy
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Address for correspondence: Carlo Riccardi, Dipartimento di Medicina Clinica e Sperimentale, Sezione di Farmacologia, Università di Perugia, Via del Giochetto, 06100 Perugia, Italy. Voice: +39 075-5857467; fax: +39 075-5857405.
 riccardi@unipg.it

Abstract

Abstract: Glucocorticoid-induced TNFR-related (GITR) protein, a member of the tumor necrosis factor receptor superfamily, is expressed in many components of the innate and adaptive immune system and modulates their activation following interaction with its ligand (GITRL). Here we review and discuss results described in previous publications where the role of the GITR/GITRL system in lung inflammation was evaluated using two experimental systems. We also discuss the proinflammatory role played by the GITR/GITRL system and the potential use of GITR fusion protein in inhibiting inflammation.

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