CCR5 Receptor

Biologic and Genetic Implications in Age-Related Diseases

Authors

  • CARMELA RITA BALISTRERI,

    1. Gruppo di Studio sull' Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, 90134 Palermo, Italy
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  • CALOGERO CARUSO,

    1. Gruppo di Studio sull' Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, 90134 Palermo, Italy
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  • MARIA PAOLA GRIMALDI,

    1. Gruppo di Studio sull' Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, 90134 Palermo, Italy
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  • FLORINDA LISTÌ,

    1. Gruppo di Studio sull' Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, 90134 Palermo, Italy
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  • SONYA VASTO,

    1. Gruppo di Studio sull' Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, 90134 Palermo, Italy
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  • VALENTINA ORLANDO,

    1. Gruppo di Studio sull' Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, 90134 Palermo, Italy
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  • ANNA MARIA CAMPAGNA,

    1. Gruppo di Studio sull' Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, 90134 Palermo, Italy
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  • DOMENICO LIO,

    1. Gruppo di Studio sull' Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, 90134 Palermo, Italy
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  • GIUSEPPINA CANDORE

    1. Gruppo di Studio sull' Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, 90134 Palermo, Italy
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Address for correspondence: Carmela Rita Balistreri, Ph.D., student, Gruppo di Studio sull'Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Corso Tukory 211, 90134 Palermo, Italy. Voice: +39-09-1655-5932; fax: +39-09-1655-5933.
 crbalistreri@unipa.it

Abstract

Abstract: The CC chemokine receptor 5 (CCR5) is a member of CC-chemokine receptor family. CCR5 has the characteristic structure of a seven transmembrane G protein–coupled receptor (GPCR), which regulates trafficking and effector functions of memory/effector Th1 cells, macrophages, NK cells, and immature dendritic cells. CCR5 and its ligands are important molecules in viral pathogenesis. CCR5 represents the co-receptor for macrophage (M) and dual (T cell and M)-tropic immunodeficiency viruses. Recent evidence has also demonstrated the role of CCR5 in a variety of human diseases, ranging from infectious and inflammatory diseases to cancer. In this article, we describe the involvement of CCR5 in two age-related diseases, atherosclerosis and Alzheimer's disease, suggesting a possible role of chemokine system on these diseases' pathophysiology. Finally, we review the data on the probable association between CCR5Δ32 deletion and cardiovascular diseases and Alzheimer's disease.

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