Vitamin D in Defense of the Human Immune Response

Authors

  • JOHN S. ADAMS,

    1. Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
    Search for more papers by this author
  • PHILIP T. LIU,

    1. Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California, USA
    2. Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Search for more papers by this author
  • RENE CHUN,

    1. Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
    Search for more papers by this author
  • ROBERT L. MODLIN,

    1. Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, California, USA
    2. Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Search for more papers by this author
  • MARTIN HEWISON

    1. Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
    Search for more papers by this author

Address for correspondence: Dr. John S. Adams, Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Room B-131, Los Angeles, CA 90048, USA. Voice: 310-423-8970; fax: 310-423-4550.
 adamsj@cshs.org

Abstract

Abstract: Defensin is a generic name reserved for an endogenously synthesized antimicrobial agent. The purpose of this review is to describe a series of discoveries that led to the proposal that 25-hydroxylated metabolites of vitamin D are key, intracellular regulators of the synthesis and action of naturally occurring defensin molecules against bacterial antigens. The discussion will (1) highlight the basic elements of human immune response that is responsive to vitamin D, (2) recount work relevant to the extrarenal expression of the vitamin D-1-hydroxlase (CYP27b1) in the macrophage as an initiator of the innate immune response, and (3) describe recent work on the relevance of the vitamin D intracrine–autocrine–paracrine system in a model of a common and devastating human disease, tuberculosis.

Ancillary