Authors all made equal contributions to the paper.
Attenuation of Colon Carcinoma Tumor Spread by Intravenous Immunoglobulin
Article first published online: 27 SEP 2007
Annals of the New York Academy of Sciences
Volume 1110, Autoimmunity, Part B Novel Applications of Basic Research pages 567–577, September 2007
How to Cite
DAMIANOVICH, M., SOLOMON, A. S., BLANK, M. and SHOENFELD, Y. (2007), Attenuation of Colon Carcinoma Tumor Spread by Intravenous Immunoglobulin. Annals of the New York Academy of Sciences, 1110: 567–577. doi: 10.1196/annals.1423.061
- Issue published online: 27 SEP 2007
- Article first published online: 27 SEP 2007
- murine colon carcinoma;
Abstract: The impact of IVIg on metastatic capacity of CT26 murine colon carcinoma cells was studied using in vitro and in vivo methods. IVIg inhibited CT26 cell proliferation and invasion through an extracellular matrix in a dose- and time-dependent manner. Systemic treatment of mice with IVIg significantly inhibited metastatic potential of CT26 colon carcinoma cells observed as tumor nodules and lung weight reduction. Treating CT26 cell-implanted rabbit corneas with IVIg led to shrinking and complete disappearance of tumor mass in 10 days. These results provide the evidence that IVIg may be considered as a supportive therapy for inhibition of colon carcinoma tumor spread.