Most of Africa's people live in rural areas and depend on agriculture for their livelihoods. These predominantly small-scale farmers face many challenges, including food insecurity, rising poverty, and natural resource degradation. To increase the productivity, profitability, and sustainability of their farms, they need greater access to affordable yield-enhancing inputs, including well-adapted seeds and new methods for integrated soil fertility management, as well as to output markets where they can convert surplus production into cash. To address these needs, the Rockefeller Foundation and the Bill and Melinda Gates Foundation established the Alliance for a Green Revolution in Africa (AGRA). AGRA is now African led and is working within the context of the comprehensive agricultural development program established by Africa's leaders. From offices in Nairobi, Kenya, and Accra, Ghana, AGRA will support work across all key aspects of the African agricultural value chain to help millions of small-scale farmers and their families lift themselves out of poverty and hunger.