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Stress-Associated or Functional Hypothalamic Amenorrhea in the Adolescent

Authors

  • James H. Liu,

    1. Departments of Reproductive Biology and Obstetrics and Gynecology, Case Western Reserve School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
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  • Arthur H. Bill

    1. Departments of Reproductive Biology and Obstetrics and Gynecology, Case Western Reserve School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
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Address for correspondence: James H. Liu, M.D., Departments of Reproductive Biology and Obstetrics and Gynecology, Case Western Reserve School of Medicine, University Hospitals Case Medical Center, 11100 Euclid Avenue, MAC 7105, Cleveland, OH 44106-5034. Voice: +1-216-844-3888. James.Liu@case.edu

Abstract

Stress-associated amenorrhea in the adolescent is likely similar to the disorder found in young reproductive-aged adults and is termed hypothalamic amenorrhea. The key defect is an abnormality in the secretion of gonadotropin-releasing hormone. This review examines the current studies that characterize the disorder and the plausible factor(s) that may account for the disturbances in gonadotropin-releasing hormone, and identifies directions for future research in this group of disorders.

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