Fluorescent Silica Nanoparticles


Address for correspondence: Otto S. Wolfbeis, Institute of Analytical Chemsitry, Chemo- and Biosensors, University of Regensburg, D-93040 Regensburg, Germany. Voice: +49-943-4065; fax: +49-943-4064. http://www.wolfbeis.de, otto.wolfbeis@chemie.uni-r.de


We report on the preparation of fluorescent silica nanoparticles (NPs). They have been prepared by (a) modification of the NPs by amino groups and subsequent introduction of amino-reactive fluorophores of various color and (b) by modification of the NPs by either azido groups or alkyne groups and subsequent conjugation to fluorophores by so-called click chemistry, which is a novel approach toward modifying silica NPs. The new NPs were characterized in terms of size and spectral properties.