Predicting Treatment Outcome in Stimulant Dependence

Authors

  • Martina Reske,

    1. Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
    Search for more papers by this author
  • Martin P. Paulus

    1. Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
    2. Psychiatry Service, Veterans Affairs San Diego Health Care System, San Diego, California, USA
    Search for more papers by this author

Address for correspondence: Martin P. Paulus, Professor in Residence, Department of Psychiatry, Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, 8950 Villa La Jolla Dr., Suite C213, La Jolla, CA 92037-0985. UCSD: Voice: +858-534-9444; fax: +858-534-9450. VA: Voice: +858-642-3390; fax: +858-642-1429. mpaulus@ucsd.edu. web: http://koso.ucsd.edu/~martin/index.html

Abstract

The purpose of this review is to highlight some of the issues that need to be addressed to optimally use functional neuroimaging as a clinical tool to predict outcomes in substance use disorders. First, the importance of recognizing the clinical heterogeneity of the substance use disorders population is highlighted. We also emphasize that empirical and theoretical analyses support the idea that the courses of substance use disorders are relatively independent of the types of substance being used. Second, various approaches to the measurement and characterization of the longitudinal courses of substance use disorders are summarized. Third, predictors of outcomes are reviewed and their limitations are discussed. Within this context, we describe aspects of our work that focus on using functional magnetic resonance imaging to predict outcomes. Fourth, we discuss future directions, critical experiments, and the utility of functional neuroimaging as a clinical tool.

Ancillary