Annals of the New York Academy of Sciences

Cover image for Vol. 1132 Myasthenia Gravis and Related Disorders 11th International Conference

June 2008

Volume 1132 Myasthenia Gravis and Related Disorders 11th International Conference

Pages xiii–xiii, 1–393

  1. Preface

    1. Top of page
    2. Preface
    3. Part I. Structure and Function of the Neuromuscular Junction
    4. Part II. Structure and Function of the Acetylcholine Receptor
    5. Part III. Muscle-Specific Kinase and Myasthenia Gravis
    6. Part IV. Congenital Myasthenic Syndromes
    7. Part V. Immunology of Autoimmune Disorders Involving Neuronal and Glial Channel Proteins
    8. Part VI. Autoimmune Pathogenesis of Myasthenia Gravis: Current Concepts
    9. Part VII. Clinical Trials of Myasthenia Gravis
    10. Part VIII. Treatments on the Horizon for Myasthenia Gravis
    11. Part IX. Panel Discussion: Thymectomy for Myasthenia Gravis
    12. List of Abstracts
    13. Erratum
    14. Index of Contributors
    1. Preface (page xiii)

      Henry J. Kaminski and Richard J. Barohn

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.043

  2. Part I. Structure and Function of the Neuromuscular Junction

    1. Top of page
    2. Preface
    3. Part I. Structure and Function of the Neuromuscular Junction
    4. Part II. Structure and Function of the Acetylcholine Receptor
    5. Part III. Muscle-Specific Kinase and Myasthenia Gravis
    6. Part IV. Congenital Myasthenic Syndromes
    7. Part V. Immunology of Autoimmune Disorders Involving Neuronal and Glial Channel Proteins
    8. Part VI. Autoimmune Pathogenesis of Myasthenia Gravis: Current Concepts
    9. Part VII. Clinical Trials of Myasthenia Gravis
    10. Part VIII. Treatments on the Horizon for Myasthenia Gravis
    11. Part IX. Panel Discussion: Thymectomy for Myasthenia Gravis
    12. List of Abstracts
    13. Erratum
    14. Index of Contributors
  3. Part II. Structure and Function of the Acetylcholine Receptor

    1. Top of page
    2. Preface
    3. Part I. Structure and Function of the Neuromuscular Junction
    4. Part II. Structure and Function of the Acetylcholine Receptor
    5. Part III. Muscle-Specific Kinase and Myasthenia Gravis
    6. Part IV. Congenital Myasthenic Syndromes
    7. Part V. Immunology of Autoimmune Disorders Involving Neuronal and Glial Channel Proteins
    8. Part VI. Autoimmune Pathogenesis of Myasthenia Gravis: Current Concepts
    9. Part VII. Clinical Trials of Myasthenia Gravis
    10. Part VIII. Treatments on the Horizon for Myasthenia Gravis
    11. Part IX. Panel Discussion: Thymectomy for Myasthenia Gravis
    12. List of Abstracts
    13. Erratum
    14. Index of Contributors
    1. Recent Structural and Mechanistic Insights into Endplate Acetylcholine Receptors (pages 53–60)

      Steven M. Sine, Fan Gao, Won Yong Lee, Nuriya Mukhtasimova, Hai-Long Wang and Andrew G. Engel

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.041

    2. Peptide-Toxin Tools for Probing the Expression and Function of Fetal and Adult Subtypes of the Nicotinic Acetylcholine Receptor (pages 61–70)

      Russell W. Teichert, Carmen C. Garcia, Joseph G. Potian, James J. Schmidt, Veit Witzemann, Baldomero M. Olivera and Joseph J. McArdle

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.015

  4. Part III. Muscle-Specific Kinase and Myasthenia Gravis

    1. Top of page
    2. Preface
    3. Part I. Structure and Function of the Neuromuscular Junction
    4. Part II. Structure and Function of the Acetylcholine Receptor
    5. Part III. Muscle-Specific Kinase and Myasthenia Gravis
    6. Part IV. Congenital Myasthenic Syndromes
    7. Part V. Immunology of Autoimmune Disorders Involving Neuronal and Glial Channel Proteins
    8. Part VI. Autoimmune Pathogenesis of Myasthenia Gravis: Current Concepts
    9. Part VII. Clinical Trials of Myasthenia Gravis
    10. Part VIII. Treatments on the Horizon for Myasthenia Gravis
    11. Part IX. Panel Discussion: Thymectomy for Myasthenia Gravis
    12. List of Abstracts
    13. Erratum
    14. Index of Contributors
    1. Response to Therapy in Myasthenia Gravis with Anti-MuSK Antibodies (pages 76–83)

      Amelia Evoli, Maria R. Bianchi, Raffaella Riso, Giacomo M. Minicuci, Anna P. Batocchi, Serenella Servidei, Flavia Scuderi and Emanuela Bartoccioni

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.012

    2. Myasthenia Gravis Seronegative for Acetylcholine Receptor Antibodies (pages 84–92)

      Angela Vincent, Maria Isabel Leite, Maria Elena Farrugia, Saiju Jacob, Stuart Viegas, Hiro Shiraishi, Olivier Benveniste, B. Paul Morgan, David Hilton-Jones, John Newsom-Davis, David Beeson and Nick Willcox

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.020

    3. Myasthenia Gravis Experimentally Induced with Muscle-specific Kinase (pages 93–98)

      Kazuhiro Shigemoto, Sachiho Kubo, Chen Jie, Naohito Hato, Yasuhito Abe, Norifumi Ueda, Naoto Kobayashi, Kenji Kameda, Katsumi Mominoki, Atsuo Miyazawa, Akihito Ishigami, Seiji Matsuda and Naoki Maruyama

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.002

  5. Part IV. Congenital Myasthenic Syndromes

    1. Top of page
    2. Preface
    3. Part I. Structure and Function of the Neuromuscular Junction
    4. Part II. Structure and Function of the Acetylcholine Receptor
    5. Part III. Muscle-Specific Kinase and Myasthenia Gravis
    6. Part IV. Congenital Myasthenic Syndromes
    7. Part V. Immunology of Autoimmune Disorders Involving Neuronal and Glial Channel Proteins
    8. Part VI. Autoimmune Pathogenesis of Myasthenia Gravis: Current Concepts
    9. Part VII. Clinical Trials of Myasthenia Gravis
    10. Part VIII. Treatments on the Horizon for Myasthenia Gravis
    11. Part IX. Panel Discussion: Thymectomy for Myasthenia Gravis
    12. List of Abstracts
    13. Erratum
    14. Index of Contributors
    1. Congenital Myasthenic Syndromes and the Formation of the Neuromuscular Junction (pages 99–103)

      David Beeson, Richard Webster, Judith Cossins, Daniel Lashley, Hayley Spearman, Susan Maxwell, Clarke R. Slater, John Newsom-Davis, Jacqueline Palace and Angela Vincent

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.049

    2. Further Observations in Congenital Myasthenic Syndromes (pages 104–113)

      Andrew G. Engel, Xin-Ming Shen, Duygu Selcen and Steven M. Sine

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.039

  6. Part V. Immunology of Autoimmune Disorders Involving Neuronal and Glial Channel Proteins

    1. Top of page
    2. Preface
    3. Part I. Structure and Function of the Neuromuscular Junction
    4. Part II. Structure and Function of the Acetylcholine Receptor
    5. Part III. Muscle-Specific Kinase and Myasthenia Gravis
    6. Part IV. Congenital Myasthenic Syndromes
    7. Part V. Immunology of Autoimmune Disorders Involving Neuronal and Glial Channel Proteins
    8. Part VI. Autoimmune Pathogenesis of Myasthenia Gravis: Current Concepts
    9. Part VII. Clinical Trials of Myasthenia Gravis
    10. Part VIII. Treatments on the Horizon for Myasthenia Gravis
    11. Part IX. Panel Discussion: Thymectomy for Myasthenia Gravis
    12. List of Abstracts
    13. Erratum
    14. Index of Contributors
    1. Lambert–Eaton Myasthenic Syndrome : Tumor versus Nontumor Forms (pages 129–134)

      Maarten J. Titulaer and Jan J.G.M. Verschuuren

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.030

  7. Part VI. Autoimmune Pathogenesis of Myasthenia Gravis: Current Concepts

    1. Top of page
    2. Preface
    3. Part I. Structure and Function of the Neuromuscular Junction
    4. Part II. Structure and Function of the Acetylcholine Receptor
    5. Part III. Muscle-Specific Kinase and Myasthenia Gravis
    6. Part IV. Congenital Myasthenic Syndromes
    7. Part V. Immunology of Autoimmune Disorders Involving Neuronal and Glial Channel Proteins
    8. Part VI. Autoimmune Pathogenesis of Myasthenia Gravis: Current Concepts
    9. Part VII. Clinical Trials of Myasthenia Gravis
    10. Part VIII. Treatments on the Horizon for Myasthenia Gravis
    11. Part IX. Panel Discussion: Thymectomy for Myasthenia Gravis
    12. List of Abstracts
    13. Erratum
    14. Index of Contributors
    1. Regulatory and Pathogenic Mechanisms in Human Autoimmune Myasthenia Gravis (pages 135–142)

      Rozen Le Panse, Géraldine Cizeron-Clairac, Mélinée Cuvelier, Frédérique Truffault, Jacky Bismuth, Patrice Nancy, Nicole Kerlero De Rosbo and Sonia Berrih-Aknin

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.019

    2. Common Cellular and Diverse Genetic Basis of Thymoma-associated Myasthenia Gravis : Role of MHC Class II and AIRE Genes and Genetic Polymorphisms (pages 143–156)

      Philipp Ströbel, Wen-Yu Chuang, Sergei Chuvpilo, Andreas Zettl, Tiemo Katzenberger, Hubert Kalbacher, Peter Rieckmann, Wilfred Nix, Berthold Schalke, Ralf Gold, Hans-Konrad Müller-Hermelink, Pärt Peterson and Alexander Marx

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.018

    3. Autoimmunizing Mechanisms in Thymoma and Thymus (pages 163–173)

      Nick Willcox, Maria Isabel Leite, Yoshihisa Kadota, Margaret Jones, Anthony Meager, Peddasomayajula Subrahmanyam, Bhaskar Dasgupta, B. Paul Morgan and Angela Vincent

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.021

    4. Treatment of Myasthenia Gravis by Preventing Acetylcholine Receptor Modulation (pages 174–179)

      Mario Losen, Pilar Martínez-Martínez, Marko Phernambucq, Janine Schuurman, Paul W.H.I. Parren and Marc H. De Baets

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.034

    5. Genetic Factors in Autoimmune Myasthenia Gravis (pages 180–192)

      Matthieu Giraud, Claire Vandiedonck and Henri-Jean Garchon

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.027

    6. CD4+ T Cells and Cytokines in the Pathogenesis of Acquired Myasthenia Gravis (pages 193–209)

      Bianca M. Conti-Fine, Monica Milani and Wei Wang

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.042

    7. Classical Complement Pathway in Experimental Autoimmune Myasthenia Gravis Pathogenesis (pages 210–219)

      Premkumar Christadoss, Erdem Tüzün, Jing Li, Shamsher S. Saini and Huan Yang

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.009

    8. Extraocular Muscle Susceptibility to Myasthenia Gravis : Unique Immunological Environment? (pages 220–224)

      Jindrich Soltys, Bendi Gong, Henry J. Kaminski, Yuefang Zhou and Linda L. Kusner

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.037

  8. Part VII. Clinical Trials of Myasthenia Gravis

    1. Top of page
    2. Preface
    3. Part I. Structure and Function of the Neuromuscular Junction
    4. Part II. Structure and Function of the Acetylcholine Receptor
    5. Part III. Muscle-Specific Kinase and Myasthenia Gravis
    6. Part IV. Congenital Myasthenic Syndromes
    7. Part V. Immunology of Autoimmune Disorders Involving Neuronal and Glial Channel Proteins
    8. Part VI. Autoimmune Pathogenesis of Myasthenia Gravis: Current Concepts
    9. Part VII. Clinical Trials of Myasthenia Gravis
    10. Part VIII. Treatments on the Horizon for Myasthenia Gravis
    11. Part IX. Panel Discussion: Thymectomy for Myasthenia Gravis
    12. List of Abstracts
    13. Erratum
    14. Index of Contributors
    1. Immunosuppression of EAMG by IVIG Is Mediated by a Disease-specific Anti-immunoglobulin Fraction (pages 244–248)

      Sara Fuchs, Tali Feferman, Roberto Meidler, Raanan Margalit, Camille Sicsic, Talma Brenner, Orgad Laub and Miriam C. Souroujon

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.032

    2. Tacrolimus for Myasthenia Gravis : A Clinical Study of 212 Patients (pages 254–263)

      José M. Ponseti, Josep Gamez, Jamal Azem, Manuel López-Cano, Ramón Vilallonga and Manuel Armengol

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.000

  9. Part VIII. Treatments on the Horizon for Myasthenia Gravis

    1. Top of page
    2. Preface
    3. Part I. Structure and Function of the Neuromuscular Junction
    4. Part II. Structure and Function of the Acetylcholine Receptor
    5. Part III. Muscle-Specific Kinase and Myasthenia Gravis
    6. Part IV. Congenital Myasthenic Syndromes
    7. Part V. Immunology of Autoimmune Disorders Involving Neuronal and Glial Channel Proteins
    8. Part VI. Autoimmune Pathogenesis of Myasthenia Gravis: Current Concepts
    9. Part VII. Clinical Trials of Myasthenia Gravis
    10. Part VIII. Treatments on the Horizon for Myasthenia Gravis
    11. Part IX. Panel Discussion: Thymectomy for Myasthenia Gravis
    12. List of Abstracts
    13. Erratum
    14. Index of Contributors
    1. Strategies for Treating Autoimmunity : Novel Insights from Experimental Myasthenia Gravis (pages 276–282)

      Matthew N. Meriggioli, Jian Rong Sheng, Liangcheng Li and Bellur S. Prabhakar

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.023

    2. Antisense Treatment for Myasthenia Gravis : Experience with Monarsen (pages 283–290)

      Jon D. Sussman, Zohar Argov, David McKee, Eli Hazum, Solli Brawer and Hermona Soreq

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.022

    3. Antigen-specific Apheresis of Pathogenic Autoantibodies from Myasthenia Gravis Sera (pages 291–299)

      Socrates J. Tzartos, Kalliopi Bitzopoulou, Ira Gavra, Grigoris Kordas, Leslie Jacobson, Kalliopi Kostelidou, George Lagoumintzis, Orestis Lazos, Kostantinos Poulas, Sotiris Sideris, Alexandros Sotiriadis, Nikos Trakas and Paraskevi Zisimopoulou

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.017

    4. Rebooting the Immune System with High-Dose Cyclophosphamide for Treatment of Refractory Myasthenia Gravis (pages 305–314)

      Daniel B. Drachman, Robert N. Adams, Rong Hu, Richard J. Jones and Robert A. Brodsky

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.033

  10. Part IX. Panel Discussion: Thymectomy for Myasthenia Gravis

    1. Top of page
    2. Preface
    3. Part I. Structure and Function of the Neuromuscular Junction
    4. Part II. Structure and Function of the Acetylcholine Receptor
    5. Part III. Muscle-Specific Kinase and Myasthenia Gravis
    6. Part IV. Congenital Myasthenic Syndromes
    7. Part V. Immunology of Autoimmune Disorders Involving Neuronal and Glial Channel Proteins
    8. Part VI. Autoimmune Pathogenesis of Myasthenia Gravis: Current Concepts
    9. Part VII. Clinical Trials of Myasthenia Gravis
    10. Part VIII. Treatments on the Horizon for Myasthenia Gravis
    11. Part IX. Panel Discussion: Thymectomy for Myasthenia Gravis
    12. List of Abstracts
    13. Erratum
    14. Index of Contributors
    1. Thoracoscopic Thymectomy with the da Vinci Robotic System for Myasthenia Gravis (pages 329–335)

      Jens C. Rückert, Mahmoud Ismail, Marc Swierzy, Holger Sobel, Patrik Rogalla, Andreas Meisel, Klaus D. Wernecke, Ralph I. Rückert and Joachim M. Müller

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.013

    2. Extended Transcervical Thymectomy in the Treatment of Myasthenia Gravis (pages 336–343)

      Sanjay G. Khicha, Larry R. Kaiser and Joseph B. Shrager

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.006

    3. Status of the Thymectomy Trial for Nonthymomatous Myasthenia Gravis Patients Receiving Prednisone (pages 344–347)

      John Newsom-Davis, Gary Cutter, Gil I. Wolfe, Henry J. Kaminski, Alfred Jaretzki III, Greg Minisman, Inmaculada Aban and Robin Conwit

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.014

  11. List of Abstracts

    1. Top of page
    2. Preface
    3. Part I. Structure and Function of the Neuromuscular Junction
    4. Part II. Structure and Function of the Acetylcholine Receptor
    5. Part III. Muscle-Specific Kinase and Myasthenia Gravis
    6. Part IV. Congenital Myasthenic Syndromes
    7. Part V. Immunology of Autoimmune Disorders Involving Neuronal and Glial Channel Proteins
    8. Part VI. Autoimmune Pathogenesis of Myasthenia Gravis: Current Concepts
    9. Part VII. Clinical Trials of Myasthenia Gravis
    10. Part VIII. Treatments on the Horizon for Myasthenia Gravis
    11. Part IX. Panel Discussion: Thymectomy for Myasthenia Gravis
    12. List of Abstracts
    13. Erratum
    14. Index of Contributors
  12. Erratum

    1. Top of page
    2. Preface
    3. Part I. Structure and Function of the Neuromuscular Junction
    4. Part II. Structure and Function of the Acetylcholine Receptor
    5. Part III. Muscle-Specific Kinase and Myasthenia Gravis
    6. Part IV. Congenital Myasthenic Syndromes
    7. Part V. Immunology of Autoimmune Disorders Involving Neuronal and Glial Channel Proteins
    8. Part VI. Autoimmune Pathogenesis of Myasthenia Gravis: Current Concepts
    9. Part VII. Clinical Trials of Myasthenia Gravis
    10. Part VIII. Treatments on the Horizon for Myasthenia Gravis
    11. Part IX. Panel Discussion: Thymectomy for Myasthenia Gravis
    12. List of Abstracts
    13. Erratum
    14. Index of Contributors
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  13. Index of Contributors

    1. Top of page
    2. Preface
    3. Part I. Structure and Function of the Neuromuscular Junction
    4. Part II. Structure and Function of the Acetylcholine Receptor
    5. Part III. Muscle-Specific Kinase and Myasthenia Gravis
    6. Part IV. Congenital Myasthenic Syndromes
    7. Part V. Immunology of Autoimmune Disorders Involving Neuronal and Glial Channel Proteins
    8. Part VI. Autoimmune Pathogenesis of Myasthenia Gravis: Current Concepts
    9. Part VII. Clinical Trials of Myasthenia Gravis
    10. Part VIII. Treatments on the Horizon for Myasthenia Gravis
    11. Part IX. Panel Discussion: Thymectomy for Myasthenia Gravis
    12. List of Abstracts
    13. Erratum
    14. Index of Contributors
    1. Index of Contributors (pages 391–393)

      Article first published online: 28 JUN 2008 | DOI: 10.1196/annals.1405.auindex_1

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