Annals of the New York Academy of Sciences

Cover image for Vol. 1139 Drug Addiction: Research Frontiers and Treatment Advances

October 2008

Volume 1139 Drug Addiction: Research Frontiers and Treatment Advances

Pages xiii–xiv, 1–501

  1. Preface

    1. Top of page
    2. Preface
    3. Part I. Gene Regulation and Drug Abuse
    4. Part II. Substituted Amphetamine Neurotoxicity
    5. Part III. Therapeutic Approaches to Drug Addiction
    6. Part IV. METH and MPTP: Similarities and Differences
    7. Part V. Psychostimulants/Cocaine
    8. Part VI. GHB/GBL/1,4-BD and Dexmethorphan
    9. Part VII. Nicotine, Marijuana, and Alcohol
    10. Index of Contributors
    1. Preface (pages xiii–xiv)

      Syed F. Ali and Michael J. Kuhar

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.000

  2. Part I. Gene Regulation and Drug Abuse

    1. Top of page
    2. Preface
    3. Part I. Gene Regulation and Drug Abuse
    4. Part II. Substituted Amphetamine Neurotoxicity
    5. Part III. Therapeutic Approaches to Drug Addiction
    6. Part IV. METH and MPTP: Similarities and Differences
    7. Part V. Psychostimulants/Cocaine
    8. Part VI. GHB/GBL/1,4-BD and Dexmethorphan
    9. Part VII. Nicotine, Marijuana, and Alcohol
    10. Index of Contributors
    1. The Expression of NMDA Receptor Subunit mRNA in Human Chronic Alcoholics : Influence of Cirrhosis and Genotype (pages 10–19)

      Justin P. Ridge, Ada M.-C. Ho, David J. Innes and Peter R. Dodd

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.053

    2. Dopamine Receptor D4 Gene −521C/T Polymorphism Is Associated with Opioid Dependence through Cold-Pain Responses (pages 20–26)

      Ada M.-C. Ho, Nelson L.-S. Tang, Ben K.-L. Cheung and Alfreda Stadlin

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.054

    3. Injection of the Neuropeptide CNP into Dopaminergic Rat Brain Areas Decreases Alcohol Intake (pages 27–33)

      Pascal Romieu, Serge Gobaille, Dominique Aunis and Jean Zwiller

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.050

    4. Transcriptional Correlates of Human Substance Use (pages 34–42)

      Elin Lehrmann and William J. Freed

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.027

    5. Association Study between Casein Kinase 1 Epsilon Gene and Methamphetamine Dependence (pages 43–48)

      T. Kotaka, H. Ujike, Y. Morita, M. Kishimoto, Y. Okahisa, T. Inada, M. Harano, T. Komiyama, T. Hori, M. Yamada, Y. Sekine, N. Iwata, M. Iyo, I. Sora, N. Ozaki and S. Kuroda

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.025

    6. Short Allele of 5-HTTLPR as a Risk Factor for the Development of Psychosis in Japanese Methamphetamine Abusers (pages 49–56)

      Norikazu Ezaki, Kazuhiko Nakamura, Yoshimoto Sekine, Ismail Thanseem, Ayyappan Anitha, Yasuhide Iwata, Masayoshi Kawai, Kiyokazu Takebayashi, Katsuaki Suzuki, Nori Takei, Masaomi Iyo, Toshiya Inada, Nakao Iwata, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Ichiro Sora, Hiroshi Ujike and Norio Mori

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.011

    7. Association Study of the Calcineurin A Gamma Subunit Gene (PPP3CC) and Methamphetamine-Use Disorder in a Japanese Population : A Collaborative Study by the Japanese Genetics Initiative for Drug Abuse (pages 57–62)

      Y. Kinoshita, M. Ikeda, H. Ujike, T. Kitajima, Y. Yamanouchi, B. Aleksic, T. Kishi, K. Kawashima, T. Ohkouchi, N. Ozaki, T. Inada, M. Harano, T. Komiyama, T. Hori, M. Yamada, Y. Sekine, M. Iyo, I. Sora and N. Iwata

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.021

    8. Glutamate Cysteine Ligase Modifier (GCLM) Subunit Gene Is Not Associated with Methamphetamine-Use Disorder or Schizophrenia in the Japanese Population (pages 63–69)

      Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Masaomi Iyo, Ichiro Sora, Yoshimoto Sekine, Norio Ozaki, Hiroshi Ujike and Nakao Iwata

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.022

    9. Alpha4 and Beta2 Subunits of Neuronal Nicotinic Acetylcholine Receptor Genes Are Not Associated with Methamphetamine-Use Disorder in the Japanese Population (pages 70–82)

      Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Masaomi Iyo, Ichiro Sora, Yoshimoto Sekine, Norio Ozaki, Hiroshi Ujike and Nakao Iwata

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.023

    10. Prostate Apoptosis Response 4 Gene Is Not Associated with Methamphetamine-Use Disorder in the Japanese Population (pages 83–88)

      Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Masaomi Iyo, Ichiro Sora, Yoshimoto Sekine, Norio Ozaki, Hiroshi Ujike and Nakao Iwata

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.024

    11. Transient Enhanced Expression of Cdk5 Activator p25 after Acute and Chronic d-Amphetamine Administration (pages 89–102)

      Estela Cecilia Mlewski, Favio Ariel Krapacher, Soledad Ferreras and Gabriela Paglini

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.039

    12. Methamphetamine-Induced Early Increase of IL-6 and TNF-α mRNA Expression in the Mouse Brain (pages 103–111)

      Joana Gonçalves, Tânia Martins, Raquel Ferreira, Nuno Milhazes, Fernanda Borges, Carlos Fontes Ribeiro, João O. Malva, Tice R. Macedo and Ana P. Silva

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.043

  3. Part II. Substituted Amphetamine Neurotoxicity

    1. Top of page
    2. Preface
    3. Part I. Gene Regulation and Drug Abuse
    4. Part II. Substituted Amphetamine Neurotoxicity
    5. Part III. Therapeutic Approaches to Drug Addiction
    6. Part IV. METH and MPTP: Similarities and Differences
    7. Part V. Psychostimulants/Cocaine
    8. Part VI. GHB/GBL/1,4-BD and Dexmethorphan
    9. Part VII. Nicotine, Marijuana, and Alcohol
    10. Index of Contributors
    1. Differential Response of Neurotensin to Methamphetamine Self-Administration : Role of Contingency (pages 112–117)

      Paul S. Frankel, Amanda J. Hoonakker and Glen R. Hanson

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.019

    2. Dopamine Disposition in the Presynaptic Process Regulates the Severity of Methamphetamine-Induced Neurotoxicity (pages 118–126)

      Donald M. Kuhn, Dina M. Francescutti-Verbeem and David M. Thomas

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.026

    3. Antagonist of M1 Muscarinic Acetylcholine Receptor Prevents Neurotoxicity Induced by Amphetamine via Nitric Oxide Pathway (pages 172–176)

      Valentina Bashkatova, Ariane Hornick, Anatoly Vanin and Helmut Prast

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.004

    4. Pathways of Methamphetamine Toxicity : Effects of Autophagy and SOD Alteration in the Spinal Cord (pages 177–185)

      Michela Ferrucci, Livia Pasquali, Antonio Paparelli, Stefano Ruggieri and Francesco Fornai

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.013

    5. Analysis of Single, Purified Inclusions as a Novel Approach to Understand Methamphetamine Neurotoxicity (pages 186–190)

      Paola Lenzi, Federica Fulceri, Gloria Lazzeri, Alessandro Casini, Stefano Ruggieri, Antonio Paparelli and Francesco Fornai

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.014

    6. Role of Autophagy during Methamphetamine Neurotoxicity (pages 191–196)

      Livia Pasquali, Gloria Lazzeri, Ciro Isidoro, Stefano Ruggieri, Antonio Paparelli and Francesco Fornai

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.016

    7. Chronic Low-Dose Oxidative Stress Induces Caspase-3-Dependent PKCδ Proteolytic Activation and Apoptosis in a Cell Culture Model of Dopaminergic Neurodegeneration (pages 197–205)

      Martha Carvour, Chunjuan Song, Siddharth Kaul, Vellareddy Anantharam, Anumantha Kanthasamy and Arthi Kanthasamy

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.020

    8. A Role for mGluR5 Receptors in Intravenous Methamphetamine Self-Administration (pages 206–211)

      Megan P. H. Osborne and M. Foster Olive

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.034

    9. Acute Increase of the Glutamate–Glutamine Cycling in Discrete Brain Areas after Administration of a Single Dose of Amphetamine (pages 212–221)

      Frederico C. Pereira, Marta R. Rolo, Elsa Marques, Vera M. Mendes, Carlos F. Ribeiro, Syed F. Ali, Teresa Morgadinho and Tice R. Macedo

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.040

    10. Influence of Chronic Exercise on the Amphetamine-Induced Dopamine Release and Neurodegeneration in the Striatum of the Rat (pages 222–231)

      Elsa Marques, Filipa Vasconcelos, Marta R. Rolo, Frederico C. Pereira, Ana P. Silva, Tice R. Macedo and Carlos F. Ribeiro

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.041

    11. Methamphetamine Changes NMDA and AMPA Glutamate Receptor Subunit Levels in the Rat Striatum and Frontal Cortex (pages 232–241)

      Patrícia F. Simões, Ana P. Silva, Frederico C. Pereira, Elsa Marques, Nuno Milhazes, Fernanda Borges, Carlos F. Ribeiro and Tice R. Macedo

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.028

    12. Effect of Acetaldehyde on Behavioral and Neurochemical Changes Induced by MK-801 in Rats (pages 259–267)

      Mónica Padilla-de la Torre, Javier Franco-Pérez, Abel Santamaría, Sonia Galvan, Edith González and Carlos Paz

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.038

  4. Part III. Therapeutic Approaches to Drug Addiction

    1. Top of page
    2. Preface
    3. Part I. Gene Regulation and Drug Abuse
    4. Part II. Substituted Amphetamine Neurotoxicity
    5. Part III. Therapeutic Approaches to Drug Addiction
    6. Part IV. METH and MPTP: Similarities and Differences
    7. Part V. Psychostimulants/Cocaine
    8. Part VI. GHB/GBL/1,4-BD and Dexmethorphan
    9. Part VII. Nicotine, Marijuana, and Alcohol
    10. Index of Contributors
    1. Serotonin (5-HT) Transporter Ligands Affect Plasma 5-HT in Rats : Implications for Medication Development (pages 268–284)

      Richard B. Rothman, Dorota Zolkowska and Michael H. Baumann

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.042

    2. Methylphenidate-Induced Alterations in Synaptic Vesicle Trafficking and Activity : Functional Consequences and Therapeutic Implications (pages 285–290)

      Trent J. Volz, Sarah J. Farnsworth, Glen R. Hanson and Annette E. Fleckenstein

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.012

    3. Neuroimaging in Human MDMA (Ecstasy) Users : A Cortical Model (pages 291–298)

      Ronald L. Cowan, Deanne M. Roberts and James M. Joers

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.007

    4. Addiction and Cognitive Functions (pages 299–306)

      Saturnino Spiga, Alessandra Lintas and Marco Diana

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.008

    5. Crucial Role of Acetaldehyde in Alcohol Activation of the Mesolimbic Dopamine System (pages 307–317)

      Marco Diana, Alessandra Tiziana Peana, Donatella Sirca, Alessandra Lintas, Miriam Melis and Paolo Enrico

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.009

  5. Part IV. METH and MPTP: Similarities and Differences

    1. Top of page
    2. Preface
    3. Part I. Gene Regulation and Drug Abuse
    4. Part II. Substituted Amphetamine Neurotoxicity
    5. Part III. Therapeutic Approaches to Drug Addiction
    6. Part IV. METH and MPTP: Similarities and Differences
    7. Part V. Psychostimulants/Cocaine
    8. Part VI. GHB/GBL/1,4-BD and Dexmethorphan
    9. Part VII. Nicotine, Marijuana, and Alcohol
    10. Index of Contributors
    1. Defining “Neuroinflammation” : Lessons from MPTP- and Methamphetamine-Induced Neurotoxicity (pages 318–330)

      James P. O'Callaghan, Krishnan Sriram and Diane B. Miller

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.032

    2. Extranigral Neurodegeneration in Parkinson's Disease : A Role for Calpain in Neurodegeneration (pages 331–336)

      Supriti Samantaray, Jonathan T. Butler, Swapan K. Ray and Naren L. Banik

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.002

    3. Methamphetamine Fails to Alter the Noradrenergic Integrity of the Heart : A Comparison with the Parkinsonism-Inducing Neurotoxin MPTP (pages 337–344)

      Riccardo Ruffoli, Paola Soldani, Livia Pasquali, Stefano Ruggieri, Antonio Paparelli and Francesco Fornai

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.017

    4. MPTP- but Not Methamphetamine-Induced Parkinsonism Extends to Catecholamine Neurons in the Gut (pages 345–349)

      Gianfranco Natale, Olga Kastsiuchenka, Livia Pasquali, Stefano Ruggieri, Antonio Paparelli and Francesco Fornai

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.015

  6. Part V. Psychostimulants/Cocaine

    1. Top of page
    2. Preface
    3. Part I. Gene Regulation and Drug Abuse
    4. Part II. Substituted Amphetamine Neurotoxicity
    5. Part III. Therapeutic Approaches to Drug Addiction
    6. Part IV. METH and MPTP: Similarities and Differences
    7. Part V. Psychostimulants/Cocaine
    8. Part VI. GHB/GBL/1,4-BD and Dexmethorphan
    9. Part VII. Nicotine, Marijuana, and Alcohol
    10. Index of Contributors
    1. Exploratory Behavior in Rats Postnatally Exposed to Cocaine and Housed in an Enriched Environment (pages 358–365)

      Ana Magalhães, Pedro Melo, Cecília Juliana Alves, Maria Amélia Tavares, Liliana De Sousa and Teresa Summavielle

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.046

    2. Hormonal, Neurochemical, and Behavioral Response to a Forced Swim Test in Adolescent Rats throughout Cocaine Withdrawal (pages 366–373)

      Cecília Juliana Alves, Ana Magalhães, Teresa Summavielle, Pedro Melo, Liliana De Sousa, Maria Amélia Tavares and Pedro R.R. Monteiro

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.047

  7. Part VI. GHB/GBL/1,4-BD and Dexmethorphan

    1. Top of page
    2. Preface
    3. Part I. Gene Regulation and Drug Abuse
    4. Part II. Substituted Amphetamine Neurotoxicity
    5. Part III. Therapeutic Approaches to Drug Addiction
    6. Part IV. METH and MPTP: Similarities and Differences
    7. Part V. Psychostimulants/Cocaine
    8. Part VI. GHB/GBL/1,4-BD and Dexmethorphan
    9. Part VII. Nicotine, Marijuana, and Alcohol
    10. Index of Contributors
    1. Characterization and Pharmacology of the GHB Receptor (pages 374–385)

      Maharaj K. Ticku and Ashok K. Mehta

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.048

    2. γ-Hydroxybutyric Acid–Induced Cognitive Deficits in the Female Adolescent Rat (pages 386–389)

      Ratna Sircar, Ashim Basak and Debashish Sircar

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.044

    3. Toluene and TCE Decrease Binding to Mu-Opioid Receptors, but Not to Benzodiazepine and NMDA Receptors in Mouse Brain (pages 390–401)

      N. Páez-Martínez, E. Ambrosio, C. García-Lecumberri, L. Rocha, G. L. Montoya and S. L. Cruz

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.031

    4. Dextromethorphan : An Emerging Drug of Abuse (pages 402–411)

      Joseph A. Banken and Howell Foster

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.003

  8. Part VII. Nicotine, Marijuana, and Alcohol

    1. Top of page
    2. Preface
    3. Part I. Gene Regulation and Drug Abuse
    4. Part II. Substituted Amphetamine Neurotoxicity
    5. Part III. Therapeutic Approaches to Drug Addiction
    6. Part IV. METH and MPTP: Similarities and Differences
    7. Part V. Psychostimulants/Cocaine
    8. Part VI. GHB/GBL/1,4-BD and Dexmethorphan
    9. Part VII. Nicotine, Marijuana, and Alcohol
    10. Index of Contributors
    1. Screening for Marijuana and Cocaine Abuse by Immunoanalysis and Gas Chromatography : An Exploratory Study in a College Population at Universidad Autonoma del Estado de Morelos in Mexico (pages 422–425)

      Sara Garcia-Jimenez, Karina Heredia-Lezama, Fernando Bilbao-Marcos, Griselda Fuentes-Lara, Antonio Monroy-Noyola and Myrna Deciga-Campos

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.018

    2. Behavioral Effects of CB2 Cannabinoid Receptor Activation and Its Influence on Food and Alcohol Consumption (pages 426–433)

      E. S. Onaivi, O. Carpio, H. Ishiguro, N. Schanz, G. R. Uhl and R. Benno

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.035

    3. Functional Expression of Brain Neuronal CB2 Cannabinoid Receptors Are Involved in the Effects of Drugs of Abuse and in Depression (pages 434–449)

      Emmanuel S. Onaivi, Hiroki Ishiguro, Jian-Ping Gong, Sejal Patel, Paul A. Meozzi, Lester Myers, Alex Perchuk, Zoila Mora, Patricia A. Tagliaferro, Eileen Gardner, Alicia Brusco, B. Emmanuel Akinshola, Qing-Rong Liu, Sanika S. Chirwa, Bruce Hope, Javier Lujilde, Toshiya Inada, Shinya Iwasaki, David Macharia, Lindsey Teasenfitz, Tadao Arinami and George R. Uhl

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.036

    4. Ultrastructural Localization of Neuronal Brain CB2 Cannabinoid Receptors (pages 450–457)

      A. Brusco, P. A. Tagliaferro, T. Saez and E. S. Onaivi

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.037

    5. Psychosocial Withdrawal Characteristics of Nicotine Compared with Alcohol and Caffeine (pages 458–465)

      Hisatsugu Miyata, Naoyuki Hironaka, Kohji Takada, Katsumasa Miyasato, Koichi Nakamura and Tomoji Yanagita

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.030

    6. Prenatal Nicotine and/or Cocaine Differentially Alters Nicotine-Induced Sensitization in Aging Offspring (pages 466–477)

      Sonya K. Sobrian, Matthew Johnston, Jewel Wright, Daniela Kuhn and Kamal Ameis

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.045

    7. Prenatal Ethanol Exposure Reduces the Expression of the Transcriptional Factor Pax6 in the Developing Rat Brain (pages 478–498)

      María Paula Aronne, Sergio Gustavo Evrard, Sebastián Mirochnic and Alicia Brusco

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.006

  9. Index of Contributors

    1. Top of page
    2. Preface
    3. Part I. Gene Regulation and Drug Abuse
    4. Part II. Substituted Amphetamine Neurotoxicity
    5. Part III. Therapeutic Approaches to Drug Addiction
    6. Part IV. METH and MPTP: Similarities and Differences
    7. Part V. Psychostimulants/Cocaine
    8. Part VI. GHB/GBL/1,4-BD and Dexmethorphan
    9. Part VII. Nicotine, Marijuana, and Alcohol
    10. Index of Contributors
    1. Index of Contributors (pages 499–501)

      Version of Record online: 6 OCT 2008 | DOI: 10.1196/annals.1432.auindex_1

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