Annals of the New York Academy of Sciences

© The New York Academy of Sciences

Cover image for Vol. 1144 Neural Signaling Opportunities for Novel Diagnostic Approaches and Therapies

November 2008

Volume 1144 Neural Signaling Opportunities for Novel Diagnostic Approaches and Therapies

Pages xi–xiii, 1–265

  1. Preface

    1. Top of page
    2. Preface
    3. Part I. New Biology of Cellular Receptors for Neuromediators: Regulation of Expression, Signal Transduction, and Mechanisms of Cross-talk
    4. Part II. Neuromediator Participation in Host Defense, Immunity, and Inflammation
    5. Part III. Neuromediators in Diseases
    6. Part IV. Neuromediators in Prenatal Development and Stress
    7. Part V. Diagnostic and Therapeutic Strategies for Neuromediators in Diseases
    8. Index of Contributors
    1. Preface (pages xi–xiii)

      Edward J. Goetzl

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.030

  2. Part I. New Biology of Cellular Receptors for Neuromediators: Regulation of Expression, Signal Transduction, and Mechanisms of Cross-talk

    1. Top of page
    2. Preface
    3. Part I. New Biology of Cellular Receptors for Neuromediators: Regulation of Expression, Signal Transduction, and Mechanisms of Cross-talk
    4. Part II. Neuromediator Participation in Host Defense, Immunity, and Inflammation
    5. Part III. Neuromediators in Diseases
    6. Part IV. Neuromediators in Prenatal Development and Stress
    7. Part V. Diagnostic and Therapeutic Strategies for Neuromediators in Diseases
    8. Index of Contributors
    1. G Protein–Coupled Receptor Structures, Molecular Associations, and Modes of Regulation (pages 1–5)

      Laurence J. Miller

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.000

    2. Discovery of Pituitary Adenylate Cyclase-Activating Polypeptide-Regulated Genes through Microarray Analyses in Cell Culture and In Vivo (pages 6–20)

      Lee E. Eiden, Babru Samal, Matthew J. Gerdin, Tomris Mustafa, David Vaudry and Nikolas Stroth

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.019

    3. Monitoring the State of Cholecystokinin Receptor Oligomerization after Ligand Binding Using Decay of Time-Resolved Fluorescence Anisotropy (pages 21–27)

      Kaleeckal G. Harikumar and Laurence J. Miller

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.004

    4. Role of Pituitary Adenylate Cyclase-Activating Polypeptide in the Pancreatic Endocrine System (pages 28–35)

      Bo Ahrén

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.003

    5. Parathyroid Hormone-Related Protein Regulates Glioma-Associated Oncogene Transcriptional Activation : Lessons Learned from Bone Development and Cartilage Neoplasia (pages 36–41)

      Benjamin A. Alman and Jay S. Wunder

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.006

    6. Molecular Mechanisms of TRPV4-Mediated Neural Signaling (pages 42–52)

      Wolfgang Liedtke

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.012

    7. The Sall2 Transcription Factor Is a Novel p75NTR Binding Protein That Promotes the Development and Function of Neurons (pages 53–55)

      Roxana Pincheira and David B. Donner

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.026

  3. Part II. Neuromediator Participation in Host Defense, Immunity, and Inflammation

    1. Top of page
    2. Preface
    3. Part I. New Biology of Cellular Receptors for Neuromediators: Regulation of Expression, Signal Transduction, and Mechanisms of Cross-talk
    4. Part II. Neuromediator Participation in Host Defense, Immunity, and Inflammation
    5. Part III. Neuromediators in Diseases
    6. Part IV. Neuromediators in Prenatal Development and Stress
    7. Part V. Diagnostic and Therapeutic Strategies for Neuromediators in Diseases
    8. Index of Contributors
    1. Diverse Mechanisms and Consequences of Immunoadoption of Neuromediator Systems (pages 56–60)

      Edward J. Goetzl, Robert C. Chan and Mahesh Yadav

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.008

    2. Substance P in Stress and Anxiety : NK-1 Receptor Antagonism Interacts with Key Brain Areas of the Stress Circuitry (pages 61–73)

      Karl Ebner, Patrik Muigg, Georg Singewald and Nicolas Singewald

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.018

    3. Human Mast Cells Stimulate Activated T Cells : Implications for Multiple Sclerosis (pages 74–82)

      Theoharis C. Theoharides, Duraisamy Kempuraj, Taxiarchis Kourelis and Akrivi Manola

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.029

    4. Vasoactive Intestinal Peptide–Mediated Th17 Differentiation : An Expanding Spectrum of Vasoactive Intestinal Peptide Effects in Immunity and Autoimmunity (pages 83–89)

      Mahesh Yadav and Edward J. Goetzl

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.020

    5. Neurokinin-1 Receptor Expression and Function in Human Macrophages and Brain : Perspective on the Role in HIV Neuropathogenesis (pages 90–96)

      Steven D. Douglas, Jian-Ping Lai, Florin Tuluc, Lynnae Schwartz and Laurie E. Kilpatrick

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.007

  4. Part III. Neuromediators in Diseases

    1. Top of page
    2. Preface
    3. Part I. New Biology of Cellular Receptors for Neuromediators: Regulation of Expression, Signal Transduction, and Mechanisms of Cross-talk
    4. Part II. Neuromediator Participation in Host Defense, Immunity, and Inflammation
    5. Part III. Neuromediators in Diseases
    6. Part IV. Neuromediators in Prenatal Development and Stress
    7. Part V. Diagnostic and Therapeutic Strategies for Neuromediators in Diseases
    8. Index of Contributors
    1. Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease (pages 97–112)

      Mark P. Mattson

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.005

    2. Diversity of Neuropathogenic Mechanisms and Implications for Neuromediation of Diseases (pages 113–115)

      Susan E. Leeman

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.017

    3. Inhibitory Effects of a Neurokinin-1 Receptor Antagonist on Postoperative Peritoneal Adhesion Formation (pages 116–126)

      Karen L. Reed, Arthur F. Stucchi, Susan E. Leeman and James M. Becker

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.010

    4. Neuropeptides, Mesenteric Fat, and Intestinal Inflammation (pages 127–135)

      Iordanes Karagiannides and Charalabos Pothoulakis

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.009

    5. Gastrin-Releasing Peptide, Immune Responses, and Lung Disease (pages 136–147)

      Simone Degan, Giselle Y. Lopez, Katharine Kevill and Mary E. Sunday

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.022

    6. The Vasoactive Intestinal Peptide Gene Is a Key Modulator of Pulmonary Vascular Remodeling and Inflammation (pages 148–153)

      Sami I. Said

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.014

  5. Part IV. Neuromediators in Prenatal Development and Stress

    1. Top of page
    2. Preface
    3. Part I. New Biology of Cellular Receptors for Neuromediators: Regulation of Expression, Signal Transduction, and Mechanisms of Cross-talk
    4. Part II. Neuromediator Participation in Host Defense, Immunity, and Inflammation
    5. Part III. Neuromediators in Diseases
    6. Part IV. Neuromediators in Prenatal Development and Stress
    7. Part V. Diagnostic and Therapeutic Strategies for Neuromediators in Diseases
    8. Index of Contributors
    1. Prenatal Alcohol Exposure Increases Vulnerability to Stress and Anxiety-Like Disorders in Adulthood (pages 154–175)

      Kim G.C. Hellemans, Pamela Verma, Esther Yoon, Wayne Yu and Joanne Weinberg

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.016

    2. Role of Various Neurotransmitters in Mediating the Long-Term Endocrine Consequences of Prenatal Alcohol Exposure (pages 176–188)

      Soon Lee, Irene Choi, Sang Kang and Catherine Rivier

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.015

    3. Perinatal Maternal Fat Intake Affects Metabolism and Hippocampal Function in the Offspring : A Potential Role for Leptin (pages 189–202)

      Claire-Dominique Walker, Lindsay Naef, Esterina D'Asti, Hong Long, Zhifang Xu, Alain Moreau and Bouziane Azeddine

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.023

  6. Part V. Diagnostic and Therapeutic Strategies for Neuromediators in Diseases

    1. Top of page
    2. Preface
    3. Part I. New Biology of Cellular Receptors for Neuromediators: Regulation of Expression, Signal Transduction, and Mechanisms of Cross-talk
    4. Part II. Neuromediator Participation in Host Defense, Immunity, and Inflammation
    5. Part III. Neuromediators in Diseases
    6. Part IV. Neuromediators in Prenatal Development and Stress
    7. Part V. Diagnostic and Therapeutic Strategies for Neuromediators in Diseases
    8. Index of Contributors
    1. Informed Development of Drugs Acting at Family B G Protein–Coupled Receptors (pages 203–209)

      Laurence J. Miller

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.001

    2. Experimental Therapeutic Strategies for Severe Sepsis : Mediators and Mechanisms (pages 210–236)

      William R. Parrish, Margot Gallowitsch-Puerta, Christopher J. Czura and Kevin J. Tracey

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.011

    3. Activation of the Proopiomelanocortin Gene with Ketoconazole as a Treatment for Parkinson's Disease : A New Hypothesis (pages 237–242)

      Alberto Halabe Bucay

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.013

    4. Opportunities and Challenges in the Discovery of New Central Nervous System Drugs (pages 243–250)

      James E. Krause and Bertrand L. Chenard

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.024

    5. Molecular Imaging to Biomarker Development in Neuroscience (pages 251–255)

      J. James Frost

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.027

    6. Studying the Brain–Gut Axis with Pharmacological Imaging (pages 256–264)

      Kirsten Tillisch, Zhuo Wang, Lisa Kilpatrick, Daniel P. Holschneider and Emeran A. Mayer

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.025

  7. Index of Contributors

    1. Top of page
    2. Preface
    3. Part I. New Biology of Cellular Receptors for Neuromediators: Regulation of Expression, Signal Transduction, and Mechanisms of Cross-talk
    4. Part II. Neuromediator Participation in Host Defense, Immunity, and Inflammation
    5. Part III. Neuromediators in Diseases
    6. Part IV. Neuromediators in Prenatal Development and Stress
    7. Part V. Diagnostic and Therapeutic Strategies for Neuromediators in Diseases
    8. Index of Contributors
    1. Index of Contributors (page 265)

      Article first published online: 21 NOV 2008 | DOI: 10.1196/annals.1418.auindex_1

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