Annals of the New York Academy of Sciences

© The New York Academy of Sciences

Cover image for Vol. 1147 Mitochondria and Oxidative Stress in Neurodegenerative Disorders

December 2008

Volume 1147 Mitochondria and Oxidative Stress in Neurodegenerative Disorders

Pages xi–xii, 1–414

  1. Preface

    1. Top of page
    2. Preface
    3. Part I. Mitochondrial Genetics and Neurodegenerative Diseases
    4. Part II. Oxidant Actions and Production in Cells
    5. Part III. Evidence for Oxidant Damage in Brains
    6. Part IV. Antioxidant Treatments
    7. Part V. Mitochondria in Different Cell Types
    8. Part VI. Mitochondrial Function in Neurodegenerative Diseases
    9. Part VII. Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol
    10. Part VIII. Changes in Mitochondria Important for Neurodegenerative Processes
    11. Part IX. Mitochondrial Effects on Genes and Gene Expression
    12. Part X. Gene Array and Proteomic Studies
    13. Part XI. Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches
    14. Index of Contributors
    1. Preface (pages xi–xii)

      Gary E. Gibson, Rajiv R. Ratan and M. Flint Beal

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.039

  2. Part I. Mitochondrial Genetics and Neurodegenerative Diseases

    1. Top of page
    2. Preface
    3. Part I. Mitochondrial Genetics and Neurodegenerative Diseases
    4. Part II. Oxidant Actions and Production in Cells
    5. Part III. Evidence for Oxidant Damage in Brains
    6. Part IV. Antioxidant Treatments
    7. Part V. Mitochondria in Different Cell Types
    8. Part VI. Mitochondrial Function in Neurodegenerative Diseases
    9. Part VII. Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol
    10. Part VIII. Changes in Mitochondria Important for Neurodegenerative Processes
    11. Part IX. Mitochondrial Effects on Genes and Gene Expression
    12. Part X. Gene Array and Proteomic Studies
    13. Part XI. Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches
    14. Index of Contributors
    1. A Mitochondrial Etiology of Neurodegenerative Diseases: Evidence from Parkinson's Disease (pages 1–20)

      Elza Khusnutdinova, Irina Gilyazova, Eduardo Ruiz-Pesini, Olga Derbeneva, Rita Khusainova, Irina Khidiyatova, Rim Magzhanov and Douglas C. Wallace

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.001

    2. Mitochondrial DNA Mutations in Disease, Aging, and Neurodegeneration (pages 21–29)

      Amy K. Reeve, Kim J. Krishnan and Doug Turnbull

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.016

    3. What Have PINK1 and HtrA2 Genes Told Us about the Role of Mitochondria in Parkinson's Disease? (pages 30–36)

      Helene Plun-Favreau, Sonia Gandhi, Alison Wood-Kaczmar, Emma Deas, Zhi Yao and Nicholas W. Wood

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.032

  3. Part II. Oxidant Actions and Production in Cells

    1. Top of page
    2. Preface
    3. Part I. Mitochondrial Genetics and Neurodegenerative Diseases
    4. Part II. Oxidant Actions and Production in Cells
    5. Part III. Evidence for Oxidant Damage in Brains
    6. Part IV. Antioxidant Treatments
    7. Part V. Mitochondria in Different Cell Types
    8. Part VI. Mitochondrial Function in Neurodegenerative Diseases
    9. Part VII. Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol
    10. Part VIII. Changes in Mitochondria Important for Neurodegenerative Processes
    11. Part IX. Mitochondrial Effects on Genes and Gene Expression
    12. Part X. Gene Array and Proteomic Studies
    13. Part XI. Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches
    14. Index of Contributors
    1. The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling (pages 37–52)

      Anatoly A. Starkov

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.015

    2. Oxidative Stress and Energy Crises in Neuronal Dysfunction (pages 53–60)

      David G. Nicholls

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.002

    3. The Nrf2–ARE Pathway : An Indicator and Modulator of Oxidative Stress in Neurodegeneration (pages 61–69)

      Jeffrey A. Johnson, Delinda A. Johnson, Andrew D. Kraft, Marcus J. Calkins, Rebekah J. Jakel, Marcelo R. Vargas and Pei-Chun Chen

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.036

  4. Part III. Evidence for Oxidant Damage in Brains

    1. Top of page
    2. Preface
    3. Part I. Mitochondrial Genetics and Neurodegenerative Diseases
    4. Part II. Oxidant Actions and Production in Cells
    5. Part III. Evidence for Oxidant Damage in Brains
    6. Part IV. Antioxidant Treatments
    7. Part V. Mitochondria in Different Cell Types
    8. Part VI. Mitochondrial Function in Neurodegenerative Diseases
    9. Part VII. Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol
    10. Part VIII. Changes in Mitochondria Important for Neurodegenerative Processes
    11. Part IX. Mitochondrial Effects on Genes and Gene Expression
    12. Part X. Gene Array and Proteomic Studies
    13. Part XI. Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches
    14. Index of Contributors
    1. Evidence of Oxidative Stress in Alzheimer's Disease Brain and Antioxidant Therapy : Lights and Shadows (pages 70–78)

      Domenico Praticò

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.010

    2. Evidence of Oxidant Damage in Huntington's Disease: Translational Strategies Using Antioxidants (pages 79–92)

      Edward C. Stack, Wayne R. Matson and Robert J. Ferrante

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.008

    3. Oxidative Stress in Parkinson's Disease : A Mechanism of Pathogenic and Therapeutic Significance (pages 93–104)

      Chun Zhou, Yong Huang and Serge Przedborski

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.023

  5. Part IV. Antioxidant Treatments

    1. Top of page
    2. Preface
    3. Part I. Mitochondrial Genetics and Neurodegenerative Diseases
    4. Part II. Oxidant Actions and Production in Cells
    5. Part III. Evidence for Oxidant Damage in Brains
    6. Part IV. Antioxidant Treatments
    7. Part V. Mitochondria in Different Cell Types
    8. Part VI. Mitochondrial Function in Neurodegenerative Diseases
    9. Part VII. Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol
    10. Part VIII. Changes in Mitochondria Important for Neurodegenerative Processes
    11. Part IX. Mitochondrial Effects on Genes and Gene Expression
    12. Part X. Gene Array and Proteomic Studies
    13. Part XI. Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches
    14. Index of Contributors
    1. Mitochondria-Targeted Antioxidants in the Treatment of Disease (pages 105–111)

      Robin A.J. Smith, Victoria J. Adlam, Frances H. Blaikie, Abdul-Rahman B. Manas, Carolyn M. Porteous, Andrew M. James, Meredith F. Ross, Angela Logan, Helena M. Cochemé, Jan Trnka, Tracy A. Prime, Irina Abakumova, Bruce A. Jones, Aleksandra Filipovska and Michael P. Murphy

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.003

    2. Development of Mitochondria-targeted Aromatic-cationic Peptides for Neurodegenerative Diseases (pages 112–121)

      Hazel H. Szeto

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.013

    3. A New Approach to Treating Alzheimer's Disease (pages 122–128)

      John P. Blass

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.022

  6. Part V. Mitochondria in Different Cell Types

    1. Top of page
    2. Preface
    3. Part I. Mitochondrial Genetics and Neurodegenerative Diseases
    4. Part II. Oxidant Actions and Production in Cells
    5. Part III. Evidence for Oxidant Damage in Brains
    6. Part IV. Antioxidant Treatments
    7. Part V. Mitochondria in Different Cell Types
    8. Part VI. Mitochondrial Function in Neurodegenerative Diseases
    9. Part VII. Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol
    10. Part VIII. Changes in Mitochondria Important for Neurodegenerative Processes
    11. Part IX. Mitochondrial Effects on Genes and Gene Expression
    12. Part X. Gene Array and Proteomic Studies
    13. Part XI. Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches
    14. Index of Contributors
    1. Postischemic Oxidative Stress Promotes Mitochondrial Metabolic Failure in Neurons and Astrocytes (pages 129–138)

      Gary Fiskum, Camelia A. Danilov, Zara Mehrabian, Linda L. Bambrick, Tibor Kristian, Mary C. McKenna, Irene Hopkins, E. M. Richards and Robert E. Rosenthal

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.026

    2. Imaging Brain Activation : Simple Pictures of Complex Biology (pages 139–170)

      Gerald A. Dienel and Nancy F. Cruz

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.011

    3. Structural Diversity of Mitochondria : Functional Implications (pages 171–179)

      Carmen A. Mannella

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.020

  7. Part VI. Mitochondrial Function in Neurodegenerative Diseases

    1. Top of page
    2. Preface
    3. Part I. Mitochondrial Genetics and Neurodegenerative Diseases
    4. Part II. Oxidant Actions and Production in Cells
    5. Part III. Evidence for Oxidant Damage in Brains
    6. Part IV. Antioxidant Treatments
    7. Part V. Mitochondria in Different Cell Types
    8. Part VI. Mitochondrial Function in Neurodegenerative Diseases
    9. Part VII. Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol
    10. Part VIII. Changes in Mitochondria Important for Neurodegenerative Processes
    11. Part IX. Mitochondrial Effects on Genes and Gene Expression
    12. Part X. Gene Array and Proteomic Studies
    13. Part XI. Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches
    14. Index of Contributors
    1. Brain Glucose Hypometabolism and Oxidative Stress in Preclinical Alzheimer's Disease (pages 180–195)

      Lisa Mosconi, Alberto Pupi and Mony J. De Leon

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.007

    2. Complexity and Heterogeneity: What Drives the Ever-changing Brain in Huntington's Disease? (pages 196–205)

      H. Diana Rosas, David H. Salat, Stephanie Y. Lee, Alexandra K. Zaleta, Nathanael Hevelone and Steven M. Hersch

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.034

    3. Multinuclear Magnetic Resonance Spectroscopy for in Vivo Assessment of Mitochondrial Dysfunction in Parkinson's Disease (pages 206–220)

      Claire Henchcliffe, Dikoma C. Shungu, Xiangling Mao, Chaorui Huang, Melissa J. Nirenberg, Bruce G. Jenkins and M. Flint Beal

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.037

    4. Oxidant-induced Changes in Mitochondria and Calcium Dynamics in the Pathophysiology of Alzheimer's Disease (pages 221–232)

      Gary E. Gibson, Saravanan S. Karuppagounder and Qingli Shi

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.038

  8. Part VII. Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol

    1. Top of page
    2. Preface
    3. Part I. Mitochondrial Genetics and Neurodegenerative Diseases
    4. Part II. Oxidant Actions and Production in Cells
    5. Part III. Evidence for Oxidant Damage in Brains
    6. Part IV. Antioxidant Treatments
    7. Part V. Mitochondria in Different Cell Types
    8. Part VI. Mitochondrial Function in Neurodegenerative Diseases
    9. Part VII. Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol
    10. Part VIII. Changes in Mitochondria Important for Neurodegenerative Processes
    11. Part IX. Mitochondrial Effects on Genes and Gene Expression
    12. Part X. Gene Array and Proteomic Studies
    13. Part XI. Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches
    14. Index of Contributors
    1. Mitochondrial and Nuclear Cross Talk in Cell Death : Parthanatos (pages 233–241)

      Shaida A. Andrabi, Ted M. Dawson and Valina L. Dawson

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.014

    2. Role of the Ubiquitin Conjugation System in the Maintenance of Mitochondrial Homeostasis (pages 242–253)

      Albert Neutzner, Giovanni Benard, Richard J. Youle and Mariusz Karbowski

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.012

    3. Developmental Restructuring of the Creatine Kinase System Integrates Mitochondrial Energetics with Stem Cell Cardiogenesis (pages 254–263)

      Susan Chung, Petras P. Dzeja, Randolph S. Faustino and Andre Terzic

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.004

    4. The Mitochondrial Antioxidants MitoE2 and MitoQ10 Increase Mitochondrial Ca2+ Load upon Cell Stimulation by Inhibiting Ca2+ Efflux from the Organelle (pages 264–274)

      Sara Leo, György Szabadkai and Rosario Rizzuto

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.019

    5. Preventing NAD+ Depletion Protects Neurons against Excitotoxicity : Bioenergetic Effects of Mild Mitochondrial Uncoupling and Caloric Restriction (pages 275–282)

      Dong Liu, Michael Pitta and Mark P. Mattson

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.028

  9. Part VIII. Changes in Mitochondria Important for Neurodegenerative Processes

    1. Top of page
    2. Preface
    3. Part I. Mitochondrial Genetics and Neurodegenerative Diseases
    4. Part II. Oxidant Actions and Production in Cells
    5. Part III. Evidence for Oxidant Damage in Brains
    6. Part IV. Antioxidant Treatments
    7. Part V. Mitochondria in Different Cell Types
    8. Part VI. Mitochondrial Function in Neurodegenerative Diseases
    9. Part VII. Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol
    10. Part VIII. Changes in Mitochondria Important for Neurodegenerative Processes
    11. Part IX. Mitochondrial Effects on Genes and Gene Expression
    12. Part X. Gene Array and Proteomic Studies
    13. Part XI. Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches
    14. Index of Contributors
    1. Impairing the Mitochondrial Fission and Fusion Balance: A New Mechanism of Neurodegeneration (pages 283–292)

      Andrew B. Knott and Ella Bossy-Wetzel

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.030

    2. The Disulfide Relay of the Intermembrane Space of Mitochondria: An Oxygen-Sensing System? (pages 293–302)

      Karl Bihlmaier, Nikola Mesecke, Christine Kloeppel and Johannes M. Herrmann

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.005

    3. Dysfunction of Mitochondria and Sarcoplasmic Reticulum in the Pathogenesis of Collagen VI Muscular Dystrophies (pages 303–311)

      Paolo Bernardi and Paolo Bonaldo

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.009

  10. Part IX. Mitochondrial Effects on Genes and Gene Expression

    1. Top of page
    2. Preface
    3. Part I. Mitochondrial Genetics and Neurodegenerative Diseases
    4. Part II. Oxidant Actions and Production in Cells
    5. Part III. Evidence for Oxidant Damage in Brains
    6. Part IV. Antioxidant Treatments
    7. Part V. Mitochondria in Different Cell Types
    8. Part VI. Mitochondrial Function in Neurodegenerative Diseases
    9. Part VII. Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol
    10. Part VIII. Changes in Mitochondria Important for Neurodegenerative Processes
    11. Part IX. Mitochondrial Effects on Genes and Gene Expression
    12. Part X. Gene Array and Proteomic Studies
    13. Part XI. Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches
    14. Index of Contributors
    1. Mitochondria and Hypoxia-induced Gene Expression Mediated by Hypoxia-inducible Factors (pages 312–320)

      Angela Chavez, Luis F. Miranda, Paola Pichiule and Juan C. Chavez

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.021

    2. Nuclear Control of Respiratory Chain Expression by Nuclear Respiratory Factors and PGC-1-Related Coactivator (pages 321–334)

      Richard C. Scarpulla

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.006

  11. Part X. Gene Array and Proteomic Studies

    1. Top of page
    2. Preface
    3. Part I. Mitochondrial Genetics and Neurodegenerative Diseases
    4. Part II. Oxidant Actions and Production in Cells
    5. Part III. Evidence for Oxidant Damage in Brains
    6. Part IV. Antioxidant Treatments
    7. Part V. Mitochondria in Different Cell Types
    8. Part VI. Mitochondrial Function in Neurodegenerative Diseases
    9. Part VII. Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol
    10. Part VIII. Changes in Mitochondria Important for Neurodegenerative Processes
    11. Part IX. Mitochondrial Effects on Genes and Gene Expression
    12. Part X. Gene Array and Proteomic Studies
    13. Part XI. Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches
    14. Index of Contributors
    1. Regulation of Forkhead Transcription Factor FoxO3a Contributes to Calorie Restriction-induced Prevention of Alzheimer's Disease-type Amyloid Neuropathology and Spatial Memory Deterioration (pages 335–347)

      Weiping Qin, Wei Zhao, Lap Ho, Jun Wang, Kenneth Walsh, Sam Gandy and Giulio Maria Pasinetti

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.024

    2. Screening for the Metabolic Basis of Neurodegeneration : Developing a Focused Proteomic Approach (pages 348–357)

      James Murray and Roderick A. Capaldi

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.025

  12. Part XI. Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches

    1. Top of page
    2. Preface
    3. Part I. Mitochondrial Genetics and Neurodegenerative Diseases
    4. Part II. Oxidant Actions and Production in Cells
    5. Part III. Evidence for Oxidant Damage in Brains
    6. Part IV. Antioxidant Treatments
    7. Part V. Mitochondria in Different Cell Types
    8. Part VI. Mitochondrial Function in Neurodegenerative Diseases
    9. Part VII. Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol
    10. Part VIII. Changes in Mitochondria Important for Neurodegenerative Processes
    11. Part IX. Mitochondrial Effects on Genes and Gene Expression
    12. Part X. Gene Array and Proteomic Studies
    13. Part XI. Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches
    14. Index of Contributors
    1. Mitochondria and Huntington's Disease Pathogenesis : Insight from Genetic and Chemical Models (pages 358–382)

      Susan E. Browne

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.018

    2. Small Molecule Activation of Adaptive Gene Expression : Tilorone or Its Analogs Are Novel Potent Activators of Hypoxia Inducible Factor-1 That Provide Prophylaxis against Stroke and Spinal Cord Injury (pages 383–394)

      Rajiv R. Ratan, Ambreena Siddiq, Leila Aminova, Brett Langley, Stephen McConoughey, Ksenia Karpisheva, Hsin-Hwa Lee, Thomas Carmichael, Harley Kornblum, Giovanni Coppola, Daniel H. Geschwind, Ahmet Hoke, Natalya Smirnova, Cameron Rink, Sashwati Roy, Chandan Sen, Michael S. Beattie, Ron P. Hart, Martin Grumet, Dongming Sun, Robert S. Freeman, Gregg L. Semenza and Irina Gazaryan

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.033

    3. Mitochondrial Approaches for Neuroprotection (pages 395–412)

      Rajnish K. Chaturvedi and M. Flint Beal

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.027

  13. Index of Contributors

    1. Top of page
    2. Preface
    3. Part I. Mitochondrial Genetics and Neurodegenerative Diseases
    4. Part II. Oxidant Actions and Production in Cells
    5. Part III. Evidence for Oxidant Damage in Brains
    6. Part IV. Antioxidant Treatments
    7. Part V. Mitochondria in Different Cell Types
    8. Part VI. Mitochondrial Function in Neurodegenerative Diseases
    9. Part VII. Cross Talk among Mitochondria, Other Cellular Organelles, and the Cytosol
    10. Part VIII. Changes in Mitochondria Important for Neurodegenerative Processes
    11. Part IX. Mitochondrial Effects on Genes and Gene Expression
    12. Part X. Gene Array and Proteomic Studies
    13. Part XI. Animal Models of Age-Related Neurodegenerative Disease Lead to Novel Therapeutic Approaches
    14. Index of Contributors
    1. Index of Contributors (pages 413–414)

      Article first published online: 8 DEC 2008 | DOI: 10.1196/annals.1427.auindex_1

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