Annals of the New York Academy of Sciences

© The New York Academy of Sciences

Cover image for Vol. 1150 Immunology of Diabetes V From Bench to Bedside

December 2008

Volume 1150 Immunology of Diabetes V From Bench to Bedside

Pages xiii–xiii, 1–330

  1. Preface

    1. Top of page
    2. Preface
    3. Part I. Special Reports
    4. Part II. The Pancreas in Type 1 Diabetes
    5. Part III. Update on Animal Models of Type 1 Diabetes
    6. Part IV. Genetics of Type 1 Diabetes: The Next Generation
    7. Part V. Toll-like Receptors and Innate Immunity in Type 1 Diabetes
    8. Part VI. Prevention or Reversal of Type 1 Diabetes
    9. Part VII. Environmental and Mechanistic Causes of Type 1 Diabetes
    10. Part VIII. Immune Response in Islet Cell and Pancreatic Transplantation
    11. Part IX. Defining the Role of Immune Response in Type 1 Diabetes
    12. Part X. Natural History of Type 1 Diabetes
    13. Part XI. Short Communications
    14. Index of Contributors
    1. Preface (page xiii)

      Carani B. Sanjeevi, Desmond A. Schatz and Mark A. Atkinson

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.066

  2. Part I. Special Reports

    1. Top of page
    2. Preface
    3. Part I. Special Reports
    4. Part II. The Pancreas in Type 1 Diabetes
    5. Part III. Update on Animal Models of Type 1 Diabetes
    6. Part IV. Genetics of Type 1 Diabetes: The Next Generation
    7. Part V. Toll-like Receptors and Innate Immunity in Type 1 Diabetes
    8. Part VI. Prevention or Reversal of Type 1 Diabetes
    9. Part VII. Environmental and Mechanistic Causes of Type 1 Diabetes
    10. Part VIII. Immune Response in Islet Cell and Pancreatic Transplantation
    11. Part IX. Defining the Role of Immune Response in Type 1 Diabetes
    12. Part X. Natural History of Type 1 Diabetes
    13. Part XI. Short Communications
    14. Index of Contributors
    1. The Environmental Determinants of Diabetes in the Young (TEDDY) Study (pages 1–13)

      TEDDY Study Group

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.062

    2. Type 1 Diabetes TrialNet–An International Collaborative Clinical Trials Network (pages 14–24)

      Jay S. Skyler, Carla J. Greenbaum, John M. Lachin, Ellen Leschek, Lisa Rafkin-Mervis, Peter Savage and Lisa Spain, the Type 1 Diabetes TrialNet Study Group

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.054

    3. What Will It Take to Get Therapies Approved for Type 1 Diabetes? (pages 25–31)

      Alexander Fleming

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.043

  3. Part II. The Pancreas in Type 1 Diabetes

    1. Top of page
    2. Preface
    3. Part I. Special Reports
    4. Part II. The Pancreas in Type 1 Diabetes
    5. Part III. Update on Animal Models of Type 1 Diabetes
    6. Part IV. Genetics of Type 1 Diabetes: The Next Generation
    7. Part V. Toll-like Receptors and Innate Immunity in Type 1 Diabetes
    8. Part VI. Prevention or Reversal of Type 1 Diabetes
    9. Part VII. Environmental and Mechanistic Causes of Type 1 Diabetes
    10. Part VIII. Immune Response in Islet Cell and Pancreatic Transplantation
    11. Part IX. Defining the Role of Immune Response in Type 1 Diabetes
    12. Part X. Natural History of Type 1 Diabetes
    13. Part XI. Short Communications
    14. Index of Contributors
    1. Islet Glia, Neurons, and β Cells : The Neuroimmune Interface in the Pathogenesis of  Type 1 Diabetes (pages 32–42)

      Hubert Tsui, Shawn Winer, Yin Chan, Dorothy Truong, Lan Tang, Jason Yantha, Geoffrey Paltser and Hans-Michael Dosch

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.033

    2. Hedgehog Signaling during Expansion of Human Pancreatic Islet-Derived Precursors (pages 43–45)

      Rita Gallo, Fabio Arturo Grieco, Lorella Marselli, Elisabetta Ferretti, Alberto Gulino, Piero Marchetti and Francesco Dotta

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.024

  4. Part III. Update on Animal Models of Type 1 Diabetes

    1. Top of page
    2. Preface
    3. Part I. Special Reports
    4. Part II. The Pancreas in Type 1 Diabetes
    5. Part III. Update on Animal Models of Type 1 Diabetes
    6. Part IV. Genetics of Type 1 Diabetes: The Next Generation
    7. Part V. Toll-like Receptors and Innate Immunity in Type 1 Diabetes
    8. Part VI. Prevention or Reversal of Type 1 Diabetes
    9. Part VII. Environmental and Mechanistic Causes of Type 1 Diabetes
    10. Part VIII. Immune Response in Islet Cell and Pancreatic Transplantation
    11. Part IX. Defining the Role of Immune Response in Type 1 Diabetes
    12. Part X. Natural History of Type 1 Diabetes
    13. Part XI. Short Communications
    14. Index of Contributors
    1. Humanized Mice for the Study of Type 1 Diabetes and Beta Cell Function (pages 46–53)

      Marie King, Todd Pearson, Aldo A. Rossini, Leonard D. Shultz and Dale L. Greiner

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.009

    2. Developing a Novel Model System to Target Insulin-Reactive CD8 T Cells (pages 54–58)

      Gwen S. Scott, Sigal Fishman, Alon Margalit, L. Khai Siew, Stephen Chapman, Li Wen, Gideon Gross and F. Susan Wong

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.040

    3. Lowered Expressions of the NF-κB Family Members in Dendritic Cells from NOD Mice are Associated with a Reduced Expression of GATA-2 (pages 59–60)

      Kazuma Takahashi, Jo Satoh and Yoshitomo Oka

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.008

    4. Measurement of CD8+ T Cell Responses in Human Type 1 Diabetes (pages 61–67)

      Emanuela Martinuzzi, François A. Lemonnier, Christian Boitard and Roberto Mallone

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.015

    5. Comparative Analysis of the Islet Proteome between NOD/Lt and ALR/Lt Mice (pages 68–71)

      Ping Yang, Manyu Li, Dehuang Guo, Feili Gong, Bao-Ling Adam, Mark A. Atkinson and Cong-Yi Wang

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.002

  5. Part IV. Genetics of Type 1 Diabetes: The Next Generation

    1. Top of page
    2. Preface
    3. Part I. Special Reports
    4. Part II. The Pancreas in Type 1 Diabetes
    5. Part III. Update on Animal Models of Type 1 Diabetes
    6. Part IV. Genetics of Type 1 Diabetes: The Next Generation
    7. Part V. Toll-like Receptors and Innate Immunity in Type 1 Diabetes
    8. Part VI. Prevention or Reversal of Type 1 Diabetes
    9. Part VII. Environmental and Mechanistic Causes of Type 1 Diabetes
    10. Part VIII. Immune Response in Islet Cell and Pancreatic Transplantation
    11. Part IX. Defining the Role of Immune Response in Type 1 Diabetes
    12. Part X. Natural History of Type 1 Diabetes
    13. Part XI. Short Communications
    14. Index of Contributors
    1. MicroRNA Genes : Are They Susceptibility Candidates for Human Type 1 Diabetes? (pages 72–75)

      Li Zhou, Hongzhi He, Jenny X. Mi, Changgui Li, Byung Lee and Qing-Sheng Mi

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.026

    2. Independent Association of Tumor Necrosis Factor Polymorphism with Type 1 Diabetes Susceptibility (pages 76–85)

      Hyoung Doo Shin, Sei Won Yang, Duk Hee Kim and Yongsoo Park

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.059

    3. HLA Class I Supertypes in Type 1 Diabetic Children in an Urban Children's Hospital (pages 86–89)

      Zoltan Antal, Irene Jarchum and Teresa P. DiLorenzo

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.005

    4. Congenic Mapping of the MHC-Linked Susceptibility to Type 1 Diabetes in the NOD Mouse : At Least Two Genes Contribute to the Idd16 Effect (pages 90–92)

      Yoshihisa Hiromine, Tomomi Fujisawa, Shinsuke Noso, Naru Babaya, Yumiko Kawabata and Hiroshi Ikegami

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.019

    5. STAT4 Polymorphism Is Associated with Early-Onset Type 1 Diabetes, but Not with Late-Onset Type 1 Diabetes (pages 93–98)

      Hye-Soon Lee, Hyewon Park, Seiwon Yang, Dukhee Kim and Yongsoo Park

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.013

    6. From Type 1, through LADA, to Type 2 Diabetes: A Continuous Spectrum? : The Evidence of the HLA-DQ Gene (pages 99–102)

      J. Lin, Z.G. Zhou, J.P. Wang, C. Zhang and G. Huang

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.036

    7. Molecular Scanning of the Gene for Thioredoxin, an Antioxidative and Antiapoptotic Protein, and Genetic Susceptibility to Type 1 Diabetes (pages 103–105)

      Hiroshi Ikegami, Masaya Ono, Tomomi Fujisawa, Yoshihisa Hiromine, Yumiko Kawabata and Eiji Yamato

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.060

    8. The Risk Conferred by HLA-DR and DQ for Type 1 Diabetes in 0–35-Years Age Group are Different in Different Regions of Sweden (pages 106–111)

      Carani B. Sanjeevi, Saikiran K. Sedimbi, Mona Landin-Olsson, Ingrid Kockum and Åke Lernmark, on behalf of the Swedish Childhood Diabetes and the Diabetes Incidence in Sweden Study Groups

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.061

  6. Part V. Toll-like Receptors and Innate Immunity in Type 1 Diabetes

    1. Top of page
    2. Preface
    3. Part I. Special Reports
    4. Part II. The Pancreas in Type 1 Diabetes
    5. Part III. Update on Animal Models of Type 1 Diabetes
    6. Part IV. Genetics of Type 1 Diabetes: The Next Generation
    7. Part V. Toll-like Receptors and Innate Immunity in Type 1 Diabetes
    8. Part VI. Prevention or Reversal of Type 1 Diabetes
    9. Part VII. Environmental and Mechanistic Causes of Type 1 Diabetes
    10. Part VIII. Immune Response in Islet Cell and Pancreatic Transplantation
    11. Part IX. Defining the Role of Immune Response in Type 1 Diabetes
    12. Part X. Natural History of Type 1 Diabetes
    13. Part XI. Short Communications
    14. Index of Contributors
    1. Closing the Circle between the Bedside and the Bench : Toll-Like Receptors in Models of Virally Induced Diabetes (pages 112–122)

      Rita Bortell, Steven C. Pino, Dale L. Greiner, Danny Zipris and Aldo A. Rossini

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.025

    2. Toll-Like Receptors and Diabetes (pages 123–132)

      F. Susan Wong and Li Wen

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.063

    3. Different KIRs Confer Susceptibility and Protection to Adults with Latent Autoimmune Diabetes in Latvian and Asian Indian Populations (pages 133–138)

      Arun Shastry, Saikiran K. Sedimbi, Raja Rajalingam, Ingrida Rumba, Alok Kanungo and C.B. Sanjeevi

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.058

    4. Innate Immune Pathways in Virus-Induced Autoimmune Diabetes (pages 139–142)

      Anjali Nair, Travis R. Wolter, Adam J. Meyers and Danny Zipris

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.004

    5. The Distribution of Adiponectin Receptors on Human Peripheral Blood Mononuclear Cells (pages 143–145)

      Terence T.L. Pang and Parth Narendran

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.021

    6. The Role of Toll-Like Receptors 3 and 9 in the Development of Autoimmune Diabetes in NOD Mice (pages 146–148)

      F. Susan Wong, Changyun Hu, Li Zhang, Wei Du, Lena Alexopoulou, Richard A. Flavell and Li Wen

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.039

    7. TLR Agonists Abrogate Co-stimulation Blockade-Induced Mixed Chimerism and Transplantation Tolerance (pages 149–151)

      David M. Miller, Thomas Thornley, Todd Pearson, Masahiro Yamazaki, Michael A. Brehm, Aldo A. Rossini and Dale L. Greiner

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.034

  7. Part VI. Prevention or Reversal of Type 1 Diabetes

    1. Top of page
    2. Preface
    3. Part I. Special Reports
    4. Part II. The Pancreas in Type 1 Diabetes
    5. Part III. Update on Animal Models of Type 1 Diabetes
    6. Part IV. Genetics of Type 1 Diabetes: The Next Generation
    7. Part V. Toll-like Receptors and Innate Immunity in Type 1 Diabetes
    8. Part VI. Prevention or Reversal of Type 1 Diabetes
    9. Part VII. Environmental and Mechanistic Causes of Type 1 Diabetes
    10. Part VIII. Immune Response in Islet Cell and Pancreatic Transplantation
    11. Part IX. Defining the Role of Immune Response in Type 1 Diabetes
    12. Part X. Natural History of Type 1 Diabetes
    13. Part XI. Short Communications
    14. Index of Contributors
    1. Exendin-4 Therapy in NOD Mice with New-Onset Diabetes Increases Regulatory T Cell Frequency (pages 152–156)

      Song Xue, Clive H. Wasserfall, Matthew Parker, Todd M. Brusko, Sean McGrail, Kieran McGrail, Marcus Moore, Martha Campbell-Thompson, Desmond A. Schatz, Mark A. Atkinson and Michael J. Haller

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.049

    2. Role of Increased ROS Dissipation in Prevention of T1D : Lessons from the ALR Mouse (pages 157–166)

      Jing Chen, Aaron M. Gusdon, Terri C. Thayer and Clayton E. Mathews

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.045

    3. Apoptotic Non–β Cells Suppress β Cell Antigen–Reactive T Cells and Induce β Cell Antigen–Specific Regulatory T Cells : Transfusion of Apoptotic Splenic Stromal Cells Prevents Type 1 Diabetes (pages 167–170)

      Chang-Qing Xia, Yushi Qiu, Ruihua Peng, Jeannette Lo-Dauer and Michael J. Clare-Salzler

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.038

    4. Persistence of Residual Beta Cells and Islet Autoimmunity during Increasing Duration of Diabetes in NOD Mice and Experimental Approaches toward Reversing New-Onset Disease with Bioactive Peptides (pages 171–176)

      Shiva Reddy, Carlos Chun Ho Cheung, Ryan Chau Chia Chai and Jessica Astrid Rodrigues

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.010

    5. TGFβ Plasmid Construction and Delivery for the Prevention of Type 1 Diabetes (pages 177–182)

      Leejin Park, Eunjig Lee, Sangkyung Lee, Minsu Lim, Hekyung Hong, Geewook Shin and Yongsoo Park

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.017

    6. Intravenous Administration of Proinsulin 1 or 2–Expressing Fiber-Mutant Recombinant Adenovirus Vector Protects against the Development of Diabetes in NOD Mice (pages 183–186)

      Katsumi Yamada, Hiroaki Moriyama, Yasuyo Okumachi, Takashi Arai, Mami Kameno, Minoru Kishi, Hisafumi Yasuda, Kenta Hara, Koichi Yokono and Masao Nagata

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.006

    7. IFN-α Can Both Protect against and Promote the Development of Type 1 Diabetes (pages 187–189)

      F. Susan Wong and Li Wen

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.031

    8. Update on Worldwide Efforts to Prevent Type 1 Diabetes (pages 190–196)

      Jay S. Skyler, for the Type 1 Diabetes TrialNet Study Group

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.055

  8. Part VII. Environmental and Mechanistic Causes of Type 1 Diabetes

    1. Top of page
    2. Preface
    3. Part I. Special Reports
    4. Part II. The Pancreas in Type 1 Diabetes
    5. Part III. Update on Animal Models of Type 1 Diabetes
    6. Part IV. Genetics of Type 1 Diabetes: The Next Generation
    7. Part V. Toll-like Receptors and Innate Immunity in Type 1 Diabetes
    8. Part VI. Prevention or Reversal of Type 1 Diabetes
    9. Part VII. Environmental and Mechanistic Causes of Type 1 Diabetes
    10. Part VIII. Immune Response in Islet Cell and Pancreatic Transplantation
    11. Part IX. Defining the Role of Immune Response in Type 1 Diabetes
    12. Part X. Natural History of Type 1 Diabetes
    13. Part XI. Short Communications
    14. Index of Contributors
    1. Tobacco Exposure and Diabetes-Related Autoantibodies in Children : Results from the ABIS Study (pages 197–199)

      AnnaKarin Johansson, Göran Hermansson and Johnny Ludvigsson, for the ABIS Study Group

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.023

    2. Variations in Incidence of Type 1 Diabetes in Different Municipalities of Stockholm (pages 200–207)

      Sreevalsam Gopinath, Eva Örtqvist, Svante Norgren, Anders Green and Carani B. Sanjeevi

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.057

    3. Eradication of Helicobactor pylori May Trigger Onset of Type 1 Diabetes : A Case Report (pages 208–209)

      Ai Tada, Naoko Komiya, Akira Shimada, Takeshi Katsuki, Yoichi Oikawa and Hiroshi Itoh

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.001

    4. Diabetogenic Effects of the Most Prevalent Enteroviruses in Finnish Sewage (pages 210–212)

      Paivi Klemola, Svetlana Kaijalainen, Petri Ylipaasto and Merja Roivainen

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.012

  9. Part VIII. Immune Response in Islet Cell and Pancreatic Transplantation

    1. Top of page
    2. Preface
    3. Part I. Special Reports
    4. Part II. The Pancreas in Type 1 Diabetes
    5. Part III. Update on Animal Models of Type 1 Diabetes
    6. Part IV. Genetics of Type 1 Diabetes: The Next Generation
    7. Part V. Toll-like Receptors and Innate Immunity in Type 1 Diabetes
    8. Part VI. Prevention or Reversal of Type 1 Diabetes
    9. Part VII. Environmental and Mechanistic Causes of Type 1 Diabetes
    10. Part VIII. Immune Response in Islet Cell and Pancreatic Transplantation
    11. Part IX. Defining the Role of Immune Response in Type 1 Diabetes
    12. Part X. Natural History of Type 1 Diabetes
    13. Part XI. Short Communications
    14. Index of Contributors
    1. Co-transplantation of Stromal Cells Interferes with the Rejection of Allogeneic Islet Grafts (pages 213–216)

      Stella Jacobson, Makiko Kumagai-Braesch, Annika Tibell, Mattias Svensson and Malin Flodström-Tullberg

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.042

    2. Anti-CD20 Treatment Prolongs Syngeneic Islet Graft Survival and Delays the Onset of Recurrent Autoimmune Diabetes (pages 217–219)

      Changyun Hu, Songyan Deng, F. Susan Wong and Li Wen

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.032

    3. Autologous Hematopoietic Stem Cell Transplantation for Type 1 Diabetes (pages 220–229)

      Júlio C. Voltarelli, Carlos E.B. Couri, Ana B.P.L. Stracieri, Maria C. Oliveira, Daniela A. Moraes, Fabiano Pieroni, George M.N. Barros, Maria Isabel A. Madeira, Kelen C.R. Malmegrim, Maria C. Foss-Freitas, Belinda P. Simões, Milton C. Foss, Elizabeth Squiers and Richard K. Burt

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.048

    4. Time Course of Islet Loss after Intraportal Transplantation (pages 230–233)

      Krystian Pawelec, Maciej Tadeusz Juszczak, Anila Kumar, Steve Hugh Powis and Martin Press

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.016

  10. Part IX. Defining the Role of Immune Response in Type 1 Diabetes

    1. Top of page
    2. Preface
    3. Part I. Special Reports
    4. Part II. The Pancreas in Type 1 Diabetes
    5. Part III. Update on Animal Models of Type 1 Diabetes
    6. Part IV. Genetics of Type 1 Diabetes: The Next Generation
    7. Part V. Toll-like Receptors and Innate Immunity in Type 1 Diabetes
    8. Part VI. Prevention or Reversal of Type 1 Diabetes
    9. Part VII. Environmental and Mechanistic Causes of Type 1 Diabetes
    10. Part VIII. Immune Response in Islet Cell and Pancreatic Transplantation
    11. Part IX. Defining the Role of Immune Response in Type 1 Diabetes
    12. Part X. Natural History of Type 1 Diabetes
    13. Part XI. Short Communications
    14. Index of Contributors
    1. Human Regulatory CD8+ T Cells : The Involvement of Cytokines (pages 234–238)

      Vitaly Ablamunits, Brygida C. Bisikirska and Kevan C. Herold

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.000

    2. Type 1 Diabetes versus Type 2 Diabetes with Onset in Persons Younger than 20 Years of Age : Results from an Indian Multicenter Study (pages 239–244)

      A. G. Unnikrishnan, Eesh Bhatia, Vijayalakshmi Bhatia, Sanjay Kumar Bhadada, Rakesh Kumar Sahay, Arun Kannan, V. Kumaravel, Dipti Sarma, Bantwal Ganapathy, Nihal Thomas, Mathew John, R. V. Jayakumar, Harish Kumar, Vasantha Nair and Carani B. Sanjeevi

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.056

    3. Conserved Epitopes in the Protein Tyrosine Phosphatase Family of Diabetes Autoantigens (pages 245–247)

      Y. Liu, J.M. Wenzlau, L. Yu, C. Patel, G.S. Eisenbarth, J.C. Hutton and H.W. Davidson

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.035

    4. Humoral Immune Response to Islet Autoantigens in Japanese Patients with Type 1 Diabetes (pages 248–251)

      Eiji Kawasaki, Genpei Kuriya, Tsuyoshi Satoh, Keiichiro Fujishima, Akie Moriuchi, Keiko Fukushima, Masako Ozaki, Norio Abiru, Hironori Yamasaki and Katsumi Eguchi

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.027

    5. Identification of a Major Humoral Epitope in Slc30A8 (ZnT8) (pages 252–255)

      Janet M. Wenzlau, Ong Moua, Yu Liu, George S. Eisenbarth, John C. Hutton and Howard W. Davidson

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.028

    6. SlC30A8 Is a Major Target of Humoral Autoimmunity in Type 1 Diabetes and a Predictive Marker in Prediabetes (pages 256–259)

      Janet M. Wenzlau, Ong Moua, Suparna A. Sarkar, Liping Yu, Marian Rewers, George S. Eisenbarth, Howard W. Davidson and John C. Hutton

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.029

    7. Prevalence of Organ-Specific Autoantibodies in Childhood- and Adult-Onset Type 1 Diabetes (pages 260–262)

      S. Allen, J. Huber and D. Devendra

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.003

    8. Carboxypeptidase-H Autoantibodies Differentiate a More Latent Subset of Autoimmune Diabetes from Phenotypic Type 2 Diabetes among Chinese Adults (pages 263–266)

      L. Yang, Z.G. Zhou, S.Z. Tan, G. Huang, P. Jin, X. Yan, X. Li, H. Peng and W. Hagopian

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.037

    9. Latent Autoimmune Diabetes in an Adult : A Case Report Including Follow-up Showing Change of Reactivity to GAD65 Antibody Epitope from IGT to IDDM (pages 267–269)

      Taro Maruyama, Ayako Koyama and Christiane S. Hampe

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.022

    10. The Sentinel Role of CD8 T Cells in Regulating CD4 T Cell Responses to Proinsulin in β-Islet Cell Autoimmunity (pages 270–272)

      Vedran Batarelo and Ivana Durinovic-Belló

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.047

    11. Diverse FOXP3 Expression in Children with Type 1 Diabetes and Celiac Disease (pages 273–277)

      Anna Kivling, Lennart Nilsson, Karin Fälth-Magnusson, Sofia Söllvander, Calle Johanson and Maria Faresjö

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.018

    12. Autoreactive T Cell Response in CD25-Negative Fraction of Peripheral Blood Mononuclear Cells in Established Type 1 Diabetes (pages 278–281)

      Hiroaki Moriyama, Reiko Kotani, Atsumi Katsuta, Mami Kameno, Takashi Arai, Yasuyo Okumachi, Minoru Kishi, Katsumi Yamada, Hisafumi Yasuda, Kenta Hara, Koichi Yokono and Masao Nagata

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.007

    13. Gene Expression Profiles Stratified according to Type 1 Diabetes Mellitus Susceptibility Regions (pages 282–289)

      Diane Meyre Rassi, Cristina Moraes Junta, Ana Lúcia Fachin, Paula Sandrin-Garcia, Stephano Mello, Guilherme Liberato Silva, Adriane Feijó Evangelista, Danielle Aparecida Magalhães, Isabela Jubé Wastowski, Janaína Oliveira Crispim, Gustavo Martelli-Palomino, Ana Paula Mores Fernandes, Neife N.H.S. Deghaide, Maria Cristina Foss-Freitas, Milton César Foss, Christiane Pienna Soares, Elza Tieme Sakamoto-Hojo, Geraldo Aleixo Silva Passos and Eduardo Antônio Donadi

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.064

  11. Part X. Natural History of Type 1 Diabetes

    1. Top of page
    2. Preface
    3. Part I. Special Reports
    4. Part II. The Pancreas in Type 1 Diabetes
    5. Part III. Update on Animal Models of Type 1 Diabetes
    6. Part IV. Genetics of Type 1 Diabetes: The Next Generation
    7. Part V. Toll-like Receptors and Innate Immunity in Type 1 Diabetes
    8. Part VI. Prevention or Reversal of Type 1 Diabetes
    9. Part VII. Environmental and Mechanistic Causes of Type 1 Diabetes
    10. Part VIII. Immune Response in Islet Cell and Pancreatic Transplantation
    11. Part IX. Defining the Role of Immune Response in Type 1 Diabetes
    12. Part X. Natural History of Type 1 Diabetes
    13. Part XI. Short Communications
    14. Index of Contributors
    1. Evaluation of Cytokine Production from Peripheral Blood Mononuclear Cells of Type 1 Diabetic Patients : Importance of the Methodologic Approach (pages 290–296)

      Maria Cristina Foss-Freitas, Norma Tiraboschi Foss, Diane Meyre Rassi, Eduardo Antônio Donadi and Milton C. Foss

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.053

    2. Insulitis in Human Type 1 Diabetes (pages 297–299)

      Toshiaki Hanafusa and Akihisa Imagawa

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.052

    3. Immunoregulatory Pathways Controlling Progression of Autoimmunity in NOD Mice : The Role of CTLA-4 and TGF-β (pages 300–310)

      Sylvaine You, Marie-Alexandra Alyanakian, Berta Segovia, Diane Damotte, Jeffrey Bluestone, Jean-François Bach and Lucienne Chatenoud

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.046

    4. Induction of Apoptosis of β Cells of the Pancreas by Advanced Glycation End-Products, Important Mediators of Chronic Complications of Diabetes Mellitus (pages 311–315)

      Minsu Lim, Leejin Park, Geewook Shin, Hekyung Hong, Incheol Kang and Yongsoo Park

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.011

  12. Part XI. Short Communications

    1. Top of page
    2. Preface
    3. Part I. Special Reports
    4. Part II. The Pancreas in Type 1 Diabetes
    5. Part III. Update on Animal Models of Type 1 Diabetes
    6. Part IV. Genetics of Type 1 Diabetes: The Next Generation
    7. Part V. Toll-like Receptors and Innate Immunity in Type 1 Diabetes
    8. Part VI. Prevention or Reversal of Type 1 Diabetes
    9. Part VII. Environmental and Mechanistic Causes of Type 1 Diabetes
    10. Part VIII. Immune Response in Islet Cell and Pancreatic Transplantation
    11. Part IX. Defining the Role of Immune Response in Type 1 Diabetes
    12. Part X. Natural History of Type 1 Diabetes
    13. Part XI. Short Communications
    14. Index of Contributors
    1. Preparation and Testing of Diabetes Autoantibody Controls (pages 316–319)

      H. Brooking, M.J. Powell, M. Amoroso, C. Betterle, B. Pedini, G. Coco, J. Furmaniak and B. Rees Smith

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.014

    2. Tumor Necrosis Factor Alpha Inducing Spatial Interactions between Calcium-Sensing Receptor and L-Type Voltage-Dependent Calcium Channel (pages 320–322)

      Jai Parkash

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.030

    3. Tracking Down Immune Markers from Alternative System Pathway Factors in a Diabetic Population (pages 323–326)

      Bushra Chaudhry, Najamul Islam, Kausar Saboohi and Nazema Ahsen

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.044

  13. Index of Contributors

    1. Top of page
    2. Preface
    3. Part I. Special Reports
    4. Part II. The Pancreas in Type 1 Diabetes
    5. Part III. Update on Animal Models of Type 1 Diabetes
    6. Part IV. Genetics of Type 1 Diabetes: The Next Generation
    7. Part V. Toll-like Receptors and Innate Immunity in Type 1 Diabetes
    8. Part VI. Prevention or Reversal of Type 1 Diabetes
    9. Part VII. Environmental and Mechanistic Causes of Type 1 Diabetes
    10. Part VIII. Immune Response in Islet Cell and Pancreatic Transplantation
    11. Part IX. Defining the Role of Immune Response in Type 1 Diabetes
    12. Part X. Natural History of Type 1 Diabetes
    13. Part XI. Short Communications
    14. Index of Contributors
    1. Index of Contributors (pages 327–330)

      Article first published online: 15 DEC 2008 | DOI: 10.1196/annals.1447.auindex_1

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