Recent studies have revealed that young infants can form expectations for the spatial location of future visual events. Four experiments examined whether 3-month-old infants also form expectations for content features of events, defined as an invariant color combination. Infants viewed a spatially alternating (left–right) sequence of varying pictures in which pictures on one side (invariant colors) always appeared with the same color combination (e.g., red/green), while on the other side (varied colors) the pictures appeared with any of 4 possible color combinations. Results indicated that infants formed a content expectation for the invariant color combination on the invariant side, such that their anticipatory responding was disrupted by a novel color combination event and by a novel pattern event. A dissociation between reactive and anticipatory eye movements in their sensitivity to the content manipulation suggests that infants' expectations for spatial and content information engage somewhat different processes.