Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review

Authors

  • G. Bagalkotkar,

    1. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. G. Bagalkotkar, S. R. Sagineedu, J. Stanslas
    Search for more papers by this author
  • S. R. Sagineedu,

    1. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. G. Bagalkotkar, S. R. Sagineedu, J. Stanslas
    Search for more papers by this author
  • M. S. Saad,

    1. Department of Plant Science, Faculty of Agriculture, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. M. S. Saad
    Search for more papers by this author
  • J. Stanslas

    Corresponding author
    1. Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. G. Bagalkotkar, S. R. Sagineedu, J. Stanslas
    2. Laboratory of Natural Products, Institute of Bioscience, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. J. Stanslas
    Search for more papers by this author

Correspondence: J. Stanslas, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. E-mail: rcxjs@medic.upm.edu.my or Jstanslas@yahoo.co.uk

Abstract

This review discusses the medicinal plant Phyllanthus niruri Linn. (Euphorbiaceae), its wide variety of phytochemicals and their pharmacological properties. The active phytochemicals, flavonoids, alkaloids, terpenoids, lignans, polyphenols, tannins, coumarins and saponins, have been identified from various parts of P. niruri. Extracts of this herb have been proven to have therapeutic effects in many clinical studies. Some of the most intriguing therapeutic properties include anti-hepatotoxic, anti-lithic, anti-hypertensive, anti-HIV and anti-hepatitis B. Therefore, studies relating to chemical characteristics and structural properties of the bioactive phytochemicals found in P. niruri are very useful for further research on this plant as many of the phytochemicals have shown preclinical therapeutic efficacies for a wide range of human diseases, including HIV/AIDS and hepatitis B.

Ancillary