New insights into the mechanisms of action of radioimmunotherapy in lymphoma
Article first published online: 18 FEB 2010
2008 Royal Pharmaceutical Society of Great Britain
Journal of Pharmacy and Pharmacology
Special Issue: Radiation Biology - can new concepts achieve better treatment outcomes?
Volume 60, Issue 8, pages 987–998, August 2008
How to Cite
Ivanov, A., Swann, R. and Illidge, T. (2008), New insights into the mechanisms of action of radioimmunotherapy in lymphoma. Journal of Pharmacy and Pharmacology, 60: 987–998. doi: 10.1211/jpp.60.8.0006
- Issue published online: 18 FEB 2010
- Article first published online: 18 FEB 2010
- Received January 31, 2008; Accpeted May 6, 2008
The exquisite sensitivity of haematological malignancies to targeted radiation alongside the impressive results achieved by the pioneers in this field suggests that radioimmunotherapy is likely to be a productive area for future clinical research. Recent experimental work has demonstrated that the combination of targeted radiation and antibody effector mechanisms are critical to long-term clearance of tumour. This review provides the background of clinical and biological insights into the mechanisms of action of radioimmunotherapy.