Effect of lipopeptides and iontophoresis on aciclovir skin delivery
Article first published online: 10 JUN 2010
© 2010 The Authors Journal compilation © 2010 Royal Pharmaceutical Society of Great Britain
Journal of Pharmacy and Pharmacology
Special Issue: Recent advances in transdermal drug delivery
Volume 62, Issue 6, pages 702–708, June 2010
How to Cite
Nicoli, S., Eeman, M., Deleu, M., Bresciani, E., Padula, C. and Santi, P. (2010), Effect of lipopeptides and iontophoresis on aciclovir skin delivery. Journal of Pharmacy and Pharmacology, 62: 702–708. doi: 10.1211/jpp.62.06.0006
- Issue published online: 10 JUN 2010
- Article first published online: 10 JUN 2010
- Received October 29, 2009Accepted February 01, 2010
- transdermal penetration
Objectives Lipopeptides are compounds derived from microorganisms that exhibit pronounced surface and emulsifying activity. The ability of lipopeptides to interact with stratum corneum lipids makes them candidates as transdermal penetration enhancers. We have investigated the potential of two lipopeptides, fengycin and surfactin, to act as enhancers for the transdermal penetration and skin accumulation of aciclovir.
Methods To investigate a possible synergistic effect, surfactin and fengycin were associated with anodal iontophoresis. Permeation experiments were performed using vertical diffusion cells and pig ear skin as barrier. Differential scanning calorimetry was used to study the interaction between fengycin and stratum corneum lipids.
Key findings The results obtained indicated that surfactin and fengycin were not suitable to enhance aciclovir flux across the skin, not even when associated with iontophoresis. Aciclovir flux was slightly decreased in passive conditions and unchanged (fengycin) or decreased (surfactin) in anodal iontophoretic conditions. When applied in passive conditions, fengycin and surfactin increased aciclovir concentration in the epidermis by a factor of 2.
Conclusions Surfactin and fengycin did not enhance aciclovir transport across the skin (not even when associated with iontophoresis) although they increased aciclovir concentration in the epidermis by a factor of 2.