1531-4995/asset/cover.gif?v=1&s=ac9e987508d442acd12556b278c60cf12b627a2e "The Laryngoscope")
Read before the Clinical Allergy Course for Otolaryngologists, Tulane University School of Medicine, New Orleans, La., November 8, 1972
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Article
Hypometabolism in allergy: A review for otolaryngologists†
Article first published online: 5 JAN 2009
DOI: 10.1288/00005537-197401000-00003
Copyright © 1974 The Triological Society
Additional Information
How to Cite
Withers, B. T. (1974), Hypometabolism in allergy: A review for otolaryngologists. The Laryngoscope, 84: 43–52. doi: 10.1288/00005537-197401000-00003
- †
Publication History
- Issue published online: 5 JAN 2009
- Article first published online: 5 JAN 2009
- Manuscript Received: 21 FEB 1973
- Manuscript Accepted: 21 FEB 1973
- Abstract
- References
- Cited By
Abstract
Treatment failure in hyposensitization therapy for allergy is frequently associated with lack of utilizable thyroid hormone in the periphery at the cell level. Basic biochemical principles and endocrinological aspects of the problem relate to the enzymatic mechanism of allergy and atopy (Godlowski). Enzymatic protein synthesis and breakdown in the mitochondria within the cells requires energy supplied by the APT/ADP cycle. In turn, energy from metabolically active thyroid hormone (T3) is necessary as a driving force for the preceding. If T3 is lacking in the process, faulty, inefficient, toxic enzymes result, which cannot completely break down ragweed or other entering antigens to symptomless metabolites. Toxic allergy symptoms result in the patient.
Diagnosis and application of corrective measures in clinical allergy cases as well as treatment precautions will be detailed in representative case reports.