Presented at the 85th Annual Meeting of the American Laryngological, Rhinological and Otological Society, Inc., Palm Beach, FL, May 4, 1982.
Article first published online: 5 JAN 2009
Copyright © 1982 The Triological Society
Volume 92, Issue 12, pages 1408–1413, December 1982
How to Cite
Wright, C. G. and Schaefer, S. D. (1982), Inner ear histopathology in patients treated with Cis-Platinum. The Laryngoscope, 92: 1408–1413. doi: 10.1288/00005537-198212000-00013
Callier Center for Communication Disorders, University of Texas at Dallas and the Department of Otolaryngology, University of Texas Health Science Center at Dallas.
- Issue published online: 5 JAN 2009
- Article first published online: 5 JAN 2009
- USPHS research grant. Grant Number: NS 16236
Temporal bone histopathology was studied in five patients (aged 51–67) who received cis-diamminedichloroplatinum (DDP) chemotherapy for head and neck squamous cell carcinoma. In each case, a sensorineural hearing loss occurred during the course of treatment and temporal bones were acquired 3–5 hours postmortem for anatomical study.
Scanning electron microscopy revealed acute degenerative changes in cochlear hair cells that appeared to be the result of drug treatment. However, the presence of age-related degeneration made it difficult to unequivocally identify hair cell loss due solely to ototoxicity.
In one patient, a decrement in vestibular function was observed during DDP treatment. Postmortem examination showed severe degeneration of the maculae and cristae which could be correlated with the absence of caloric response seen after chemotherapy.