From the Division of Otolaryngology-Head and Neck Surgery (M.S. and B.B.), Department of Pathology (J.T.), Division of Audiology and Speech Pathology (S.L.), and Division of Medical Oncology (A.L. and H.A.H.).
1983 Eastern Section Triological Paper
Article first published online: 5 JAN 2009
Copyright © 1983 The Triological Society
Volume 93, Issue 12, pages 1554–1559, December 1983
How to Cite
Strauss, M., Towfighi, J., Lord, S., Lipton, A., Harvey, H. A. and Brown, B. (1983), Cis-platinum Ototoxicity: Clinical experience and temporal bone histopathology. The Laryngoscope, 93: 1554–1559. doi: 10.1288/00005537-198312000-00007
Presented at the Meeting of the Eastern Section of the American Laryngological, Rhinological and Otological Society, Inc., New York, NY, January 28, 1983.
- Issue published online: 5 JAN 2009
- Article first published online: 5 JAN 2009
A clinical and pathologic study of cis-platinum ototoxicity was performed. Twenty-four patients treated with cis-platinum for head and neck cancer were studied prospectively. Post cis-platinum hearing losses were subclinical, detected in 25% of patients, isolated to 4 and 8 kHz, and did not exceed 25 dB at any frequency.
Temporal bones from a 9-year-old with frontal lobe astrocytoma and with cis-platinum ototoxicity were studied with routine and special techniques to elucidate oto and neurotoxicity. Degenerative changes in the outer hair cells in the lower turns of the cochlea, in the spiral ganglion, and cochlear nerve were the most striking findings.