From the Department of Otolaryngology, University of Minnesota Hospitals, Minneapolis, MN.
1983 Eastern Section Triological Paper
Article first published online: 5 JAN 2009
Copyright © 1983 The Triological Society
Volume 93, Issue 12, pages 1566–1568, December 1983
How to Cite
Berlinger, N. T. and Schachern, P. (1983), Myofibroblasts in chronic otitis media. The Laryngoscope, 93: 1566–1568. doi: 10.1288/00005537-198312000-00009
Presented at the Meeting of the Eastern Section of the American Laryngological, Rhinological and Otological Society, Inc., New York, NY, January 28, 1983.
- Issue published online: 5 JAN 2009
- Article first published online: 5 JAN 2009
Cells which may be tentatively described as myofibroblasts have been identified by transmission electron microscopy from samples of inflammatory tissue present in the tympanic cavity of ears demonstrating clinical chronic otitis media. These cells possess the ultra-structural characteristics of a markedly indented nucleus, well organized bundles of cytoplasmic microfilaments, and plasmalemma specializations resembling desmosomes. Myofibroblasts are contractile cells which are present in a number of pathological conditions characterized by tissue contraction or distortion such as hepatic cirrhosis, Dupuytren's contracture, and hypertrophic scars. It is possible to hypothesize that myofibroblasts in chronic otitis media may exert synchronized contractile forces which distort the tympanic membrane or ossicular chain and thus lead to conductive hearing loss.