From the Departments of Pathology (T.B.A.), Anatomy (P.J.S.) and Surgery, Division of Otorhinolaryngology (G.R.H.), University of Texas Health Science Center, San Antonio, TX.
Autoradiographic evidence of sex steroid receptors in laryngeal tissues of the baboon (papio cynocephalus)†
Article first published online: 5 JAN 2009
Copyright © 1983 The Triological Society
Volume 93, Issue 12, pages 1607–1611, December 1983
How to Cite
Aufdemorte, T. B., Sheridan, P. J. and Holt, G. R. (1983), Autoradiographic evidence of sex steroid receptors in laryngeal tissues of the baboon (papio cynocephalus). The Laryngoscope, 93: 1607–1611. doi: 10.1288/00005537-198312000-00013
- Issue published online: 5 JAN 2009
- Article first published online: 5 JAN 2009
- National Heart, Lung, and Blood Institute. Grant Number: HL-19362
- National Institute of Neurological and Communicative Disorders and Stroke. Grant Number: RCDA-NS-00164 and NS-12933
A number of studies have implicated the gonadal steroids as significant factors in laryngeal development and disease. In addition, antiandrogens are receiving limited trials in the treatment of laryngeal carcinoma. However, there is little experimental data to document the presence, and more specifically the location of receptors for the sex steroid hormones in the larynx. The purpose of this study is to provide such data. Utilizing an autoradiographic technique, tissues from baboons injected with tritiated estradiol (3H-E2) or dihydrotestosterone testosterone (3H-DHT) were examined and analyzed. The data gathered confirmed that the larynx is rich in receptors for these steroids and that there are specific patterns of distribution of receptor positive cells. The vocalis muscle and other mesenchymal tissues contained the largest number of receptors, while ciliated columnar and stratified squamous epithelium were negative. The significance of these findings is discussed.