Deficient immunity in head and neck cancer due to excessive monocyte production of prostaglandins

Authors

  • Norman T. Berlinger M.D., Ph.D.

    Corresponding author
    1. Minneapolis, MN.
    • Department of Otolaryngology, University of Minnesota Hospitals, Mayo Box 396, Minneapolis, MN 55455
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  • Presented at the Meeting of the Middle Section of the American Laryngological, Rhinological and Otological Society, Inc., St. Louis, MO, January 21, 1983.

  • From the Department of Otolaryngology, University of Minnesota Hospitals, Minneapolis, MN.

Abstract

Monocytes from patients with head and neck cancer produce excessive PGE2 which seems to be associated with decreased lymphoproliferation in vitro. This may be n pathological exaggeration of a normal homeostatic mechanism. It is speculated that a stimulus for excessive PGE2 production could be immune complexes. Although PGE2 suppresses many important immune processes relevant for neoplasia, it can also have complex and diverse effects on tumor cells. Caution should be exercised with human trials of prostaglandin synthctase inhibitors such as indomethacin.

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