1531-4995/asset/cover.gif?v=1&s=ac9e987508d442acd12556b278c60cf12b627a2e "The Laryngoscope")
Presented as a Candidate's Thesis to the American Laryngological, Rhinological and Otological Society, Inc., October 1986.
1531-4995/asset/olbannerleft.gif?v=1&s=2ca441e35383a97ac6ef676dc895f0f8809844aa)
Candidate's Thesis
Increased spiral ganglion cell survival in electrically stimulated, deafened guinea pig cochleae†
Article first published online: 4 JAN 2009
DOI: 10.1288/00005537-198707000-00012
Copyright © 1987 The Triological Society
Additional Information
How to Cite
Lousteau, R. J. (1987), Increased spiral ganglion cell survival in electrically stimulated, deafened guinea pig cochleae. The Laryngoscope, 97: 836–842. doi: 10.1288/00005537-198707000-00012
- †
Publication History
- Issue published online: 4 JAN 2009
- Article first published online: 4 JAN 2009
- Abstract
- References
- Cited By
Abstract
For implanted electronic prostheses to function successfully in the deaf, residual spiral ganglion neurons are presumed to be necessary. Several studies have tried to determine the effects cochlear electrode implantation and electrical stimulation have on the neurons of the spiral ganglion. Little work has been published, however, on the trophic effects of electrical stimulation on cell survival after cochlear damage by ototoxicity. This report presents the results of an investigation to determine the effects of early intrncochlear electrical stimulation on spiral ganglion neuron survival after chemically induced deafness in young guinea pigs. A significantly larger number of spiral ganglion cells remained in stimulated ears 6 weeks after deafening than were seen in the unstimulated ears of the same animals. These results suggest that early implantation after acquired deafness may affect the success obtainable with electronic hearing prostheses.