Multiple synchronous and metachronous cancers of the upper aerodigestive tract: A nine-year study
Article first published online: 4 JAN 2009
Copyright © 1989 The Triological Society
Volume 99, Issue 12, pages 1267–1273, December 1989
How to Cite
Panosetti, E., Luboinski, B., Mamelle, G. and Richard, J.-M. (1989), Multiple synchronous and metachronous cancers of the upper aerodigestive tract: A nine-year study. The Laryngoscope, 99: 1267–1273. doi: 10.1288/00005537-198912000-00011
- Issue published online: 4 JAN 2009
- Article first published online: 4 JAN 2009
- Manuscript Accepted: 20 APR 1989
Three hundred fifty (42.1%) of these multiple cancers were considered synchronous, while 480 (57.9%) were classified as metachronous.
Fifty percent of the metachronous cancers occurred within 31 months after the first primary; the mean time between the first primary and the second primary was 45 months. Approximately 22% of second primaries were found more than 5 years after the initial tumor.
Five-year survival rates were higher in metachronous cancers (55%) than in synchronous cancers (18%). Survival rates varied according to the treatment. In 49.4% of synchronous tumors the treatment had to be modified because of the presence of two cancers. In these patients, 5-year survival rates were as low as 8%.
In synchronous cancers that required no modification of the treatment, the prognosis was better and the survival rate was 28%. The preferential anatomical location of the second synchronous and metachronous cancers is discussed for first primaries situated in the oral cavity (103 cases), the oropharynx (120 cases), the hypopharynx (92 cases), and the larynx (87 cases).
Second primaries in the esophagus were mostly synchronous cancers while, in the lung, second cancers were more frequently metachronous tumors.