Article

Orthotopic laryngeal transplantation: Is it time?†

  1. Gerald S. Berke MD1,2,*,
  2. Robert M. Block MD1,
  3. Steven Sloan MD1,
  4. Joel Sercarz MD1,
  5. Ming Ye MD2

Article first published online: 4 JAN 2009

DOI: 10.1288/00005537-199308000-00006

Issue

The Laryngoscope

The Laryngoscope

Volume 103, Issue 8, pages 857–864, August 1993

Additional Information

How to Cite

Berke, G. S., Block, R. M., Sloan, S., Sercarz, J. and Ye, M. (1993), Orthotopic laryngeal transplantation: Is it time?. The Laryngoscope, 103: 857–864. doi: 10.1288/00005537-199308000-00006

Author Information

  1. 1

    Division of Head and Neck Surgery, UCLA School of Medicine, Los Angeles

  2. 2

    Division of Head and Neck Surgery, Wadsworth Veterans Administration Medical Center, Los Angeles

*Division of Head and Neck Surgery, UCLA School of Medicine, 10833 LeConte Ave., CHS62–126, Los Angeles, CA 90024

  1. †

    Presented at the 95th Annual Meeting of the American Laryngological, Rhinological and Otological Society, Inc., Palm Desert, Calif., April 15, 1992.

Publication History

  1. Issue published online: 4 JAN 2009
  2. Article first published online: 4 JAN 2009

Funded by

  • NIH-NIDCD. Grant Number: USHHS DC00855
  • Veterans Administration Rehabilitation Research and Development Merit Review

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Abstract

The notion of returning phonatory and respiratory function by transplanting larynges has fascinated and challenged the minds of laryngologists for many years. In the past, the problems of revascularization, tissue rejection, and physiologic vocal fold motion have stymied the success of research in this area. Today, advances in microvascular surgery, graft versus host response, and selective reinnervation have made laryngeal transplantation a theoretical, if not a practical reality. Despite this progress, serious ethical and fiscal considerations remain unresolved. This report will discuss these advances as well as concerns and will present the current UCLA laryngeal physiology laboratory experience with canine laryngeal transplantation.

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