Presented at the 95th Annual Meeting of the American Laryngological, Rhinological and Otological Society, Inc., Palm Desert, Calif., April 15, 1992.
Orthotopic laryngeal transplantation: Is it time?†
Article first published online: 4 JAN 2009
Copyright © 1993 The Triological Society
Volume 103, Issue 8, pages 857–864, August 1993
How to Cite
Berke, G. S., Block, R. M., Sloan, S., Sercarz, J. and Ye, M. (1993), Orthotopic laryngeal transplantation: Is it time?. The Laryngoscope, 103: 857–864. doi: 10.1288/00005537-199308000-00006
- Issue published online: 4 JAN 2009
- Article first published online: 4 JAN 2009
- NIH-NIDCD. Grant Number: USHHS DC00855
- Veterans Administration Rehabilitation Research and Development Merit Review
The notion of returning phonatory and respiratory function by transplanting larynges has fascinated and challenged the minds of laryngologists for many years. In the past, the problems of revascularization, tissue rejection, and physiologic vocal fold motion have stymied the success of research in this area. Today, advances in microvascular surgery, graft versus host response, and selective reinnervation have made laryngeal transplantation a theoretical, if not a practical reality. Despite this progress, serious ethical and fiscal considerations remain unresolved. This report will discuss these advances as well as concerns and will present the current UCLA laryngeal physiology laboratory experience with canine laryngeal transplantation.